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Drugs

, Volume 73, Issue 5, pp 407–426 | Cite as

Clinical Strategies to Enhance the Efficacy of Nicotine Replacement Therapy for Smoking Cessation: A Review of the Literature

  • Matthew J. Carpenter
  • Bianca F. Jardin
  • Jessica L. Burris
  • Amanda R. Mathew
  • Robert A. Schnoll
  • Nancy A. Rigotti
  • K. Michael Cummings
Review Article

Abstract

A number of smoking cessation pharmacotherapies have led to increases in quitting and thus to significant benefits to public health. Among existing medications, nicotine replacement therapy (NRT) has been available the longest, has the largest literature base in support, and is the only option for over-the-counter access. While the short-term efficacy of NRT is well documented in clinical trials, long-term abstinence rates associated with using NRT are modest, as most smokers will relapse. This literature review examines emerging clinical strategies to improve NRT efficacy. After an initial overview of NRT and its FDA-approved indications for use, we review randomized trials in which clinical delivery of NRT was manipulated and tested, in an attempt to enhance efficacy, through (1) duration of use (pre-quit and extended use), (2) amount of use (high-dose and combination NRT), (3) tailoring to specific smoker groups (genotype and phenotype), or (4) use of NRT for novel purposes (relapse prevention, temporary abstinence, cessation induction). Outcomes vary within and across topic area, and we highlight areas that offer stronger promise. Combination NRT likely represents the most promising strategy moving forward; other clinical strategies offer conflicting evidence but deserve further testing (pre-quit NRT or tailored treatment) or offer potential utility but are in need of further, direct tests. Some areas, though based on a limited set of studies, do not offer great promise (high-dose and extended treatment NRT). We conclude with a brief discussion of emergent NRT products (e.g., oral nicotine spray, among others), which may ultimately offer greater efficacy than current formulations. In order to further lower the prevalence of smoking, novel strategies designed to optimize NRT efficacy are needed.

Keywords

Nicotine Nicotine Replacement Therapy Nicotine Patch Abstinence Rate Point Prevalence Abstinence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Funding

This work was supported by NIH Grants K23DA020482 (MJC) and R01DA021619 (MJC) and with additional support by P30CA138313 at the Hollings Cancer Center. Dr. Burris was supported by T32DA007288 from NIDA.

Conflicts of Interest

Dr. Schnoll serves as a consultant for GlaxoSmithKline and Pfizer. Dr. Rigotti has received royalties for chapters on smoking cessation from UpToDate, Inc., and is an unpaid consultant to Pfizer and Alere. Dr. Cummings has received grant funds from Pfizer and Nabi Pharmaceuticals, has served as consultant to Pfizer, and currently serves as a paid expert witness on behalf of plaintiffs in litigation against the tobacco industry. Drs. Scholl, Rigotti, and Cummings all receive funding from NIH, but funding from their consulting and grants was not used to support the present work. Drs. Carpenter, Jardin, and Burris, and Ms. Mathew do not report any conflicts of interest.

Acknowledgments

The authors thank Ms. Amy Wahlquist for assistance in preparation of tables.

References

  1. 1.
    USDHS. State-specific prevalence and trends in adult cigarette smoking—United States, 1998–2007. MMWR. 2009;58:221–6.Google Scholar
  2. 2.
    USDHS. Current cigarette smoking among adults—United States, 2011. MMWR. 2012;61:889–94.Google Scholar
  3. 3.
    Méndez D, Alshanqeety O, Warner KE. The potential impact of smoking control policies on future global smoking trends. Tob Control. 2013;22:46–51.PubMedCrossRefGoogle Scholar
  4. 4.
    USDHS. Cigarette smoking among adults—United States, 2007. MMWR. 2008;57:1221–6.Google Scholar
  5. 5.
    USDHS. Quitting smoking among adults—United States, 2001–2010. MMWR. 2011;60:1513–9.Google Scholar
  6. 6.
    Cokkinides VE, Ward E, Jemal A, Thun MJ. Under-use of smoking-cessation treatments: results from the National Health Interview Survey, 2000. Am J Prev Med. 2005;28:119–22.PubMedCrossRefGoogle Scholar
  7. 7.
    Ryan KK, Garrett-Mayer E, Alberg AJ, Cartmell KB, Carpenter MJ. Predictors of cessation pharmacotherapy use among African American and non-Hispanic white smokers. Nicotine Tob Res. 2011;13:646–52.PubMedCrossRefGoogle Scholar
  8. 8.
    Shiffman S, Brockwell SE, Pillitteri JL, Gitchell JG. Individual differences in adoption of treatment for smoking cessation: demographic and smoking history characteristics. Drug Alcohol Depend. 2008;93:121–31.PubMedCrossRefGoogle Scholar
  9. 9.
    Shiffman S, Brockwell SE, Pillitteri JL, Gitchell JG. Use of smoking-cessation treatments in the United States. Am J Prev Med. 2008;34:102–11.PubMedCrossRefGoogle Scholar
  10. 10.
    Fix BV, Hyland A, Rivard C, McNeill A, Fong GT, Borland R, et al. Usage patterns of stop smoking medications in Australia, Canada, the United Kingdom, and the United States: findings from the 2006–2008 International Tobacco Control (ITC) Four Country Survey. Int J Environ Res Public Health. 2011;8(1):222–33.PubMedCrossRefGoogle Scholar
  11. 11.
    Kotz D, Fidler JA, West R. Did the introduction of varenicline in England substitute for or add to the use of other smoking cessation medications? Nicotine Tob Res. 2011;13:793–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Amodei N, Lamb RJ. Over-the-counter nicotine replacement therapy: can its impact on smoking cessation be enhanced? Psychol Addict Behav. 2008;22:472–85.PubMedCrossRefGoogle Scholar
  13. 13.
    Carpenter MJ, Alberg AJ, Gray KM, Saladin ME. Motivating the unmotivated for health behavior change: a randomized trial of cessation induction for smokers. Clin Trials. 2010;7:157–66.PubMedCrossRefGoogle Scholar
  14. 14.
    Carpenter MJ, Hughes JR, Gray KM, Wahlquist AE, Saladin ME, Alberg AJ. Nicotine therapy sampling to induce quit attempts among smokers unmotivated to quit: a randomized clinical trial. Arch Intern Med. 2011;171:1901–7.PubMedCrossRefGoogle Scholar
  15. 15.
    Carpenter MJ, Hughes JR, Solomon LJ, Callas PW. Both smoking reduction with nicotine replacement therapy and motivational advice increase future cessation among smokers unmotivated to quit. J Consult Clin Psychol. 2004;72:371–81.PubMedCrossRefGoogle Scholar
  16. 16.
    Giardina TD, Hyland A, Bauer UE, Cummings KM. Which population-based interventions would motivate smokers to think seriously about stopping smoking? Am J Health Promot. 2004;18:405–8.PubMedCrossRefGoogle Scholar
  17. 17.
    Hughes JR, Carpenter MJ. Does smoking reduction increase future cessation and decrease disease risk? A qualitative review. Nicotine Tob Res. 2006;8:739–49.PubMedCrossRefGoogle Scholar
  18. 18.
    Fiore MC, Jaen CR, Baker TB, Bailey WC, Benowitz NL, Curry SJ, et al. Treating tobacco use and dependence: 2008 Update. Clinical Practice Guideline. Rockville: US Public Health Service; 2008.Google Scholar
  19. 19.
    Zwar N, Richmond R, Borland R, Peters M, Litt J, Bell J, et al. Supporting smoking cessation: a guide for health professionals. The Royal Australian College of General Practitioners, Melbourne; 2011.Google Scholar
  20. 20.
    ENSP. European Network for Smoking and Tobacco Prevention. 2012. http://www.ensp.org/ (Accessed March 11 2013).
  21. 21.
    Jorenby DE, Leischow SJ, Nides MA, Rennard SI, Johnston JA, Hughes AR, et al. A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med. 1999;340:685–91.PubMedCrossRefGoogle Scholar
  22. 22.
    Tonnesen P, Tonstad S, Hjalmarson A, Lebargy F, Van Spiegel PI, Hider A, et al. A multicentre, randomised, double-blind, placebo-controlled, 1-year study of bupropion SR for smoking cessation. J Intern Med. 2003;254:184–92.PubMedCrossRefGoogle Scholar
  23. 23.
    Simon JA, Duncan C, Carmody TP, Hudes ES. Bupropion for smoking cessation. Arch Intern Med. 2004;164:1797–803.PubMedCrossRefGoogle Scholar
  24. 24.
    Gonzales D, Rennard SI, Nides M, Oncken C, Azoulay S, Billing CB, et al. Varenicline, an alpha4 beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA. 2006;296:47–55.PubMedCrossRefGoogle Scholar
  25. 25.
    Jorenby DE, Hays JT, Rigotti NA, Azoulay S, Watsky EJ, Williams KE, et al. Efficacy of varenicline, an alpha beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA. 2006;296:56–63.PubMedCrossRefGoogle Scholar
  26. 26.
    David SP, Brown RA, Papandonatos GD, Kahler CW, Lloyd-Richardson EE, Munafo MR, et al. Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation. Nicotine Tob Res. 2007;9(8):821–33.PubMedCrossRefGoogle Scholar
  27. 27.
    Ebbert JO, Croghan IT, Sood A, Schroeder DR, Hays JT, Hurt RD. Varenicline and bupropion sustained-release combination therapy for smoking cessation. Nicotine Tob Res. 2009;11:234–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Garrison GD, Dugan SE. Varenicline: a first-line treatment option for smoking cessation. Clin Ther. 2009;31:463–91.PubMedCrossRefGoogle Scholar
  29. 29.
    Rigotti NA, Pipe AL, Benowitz NL, Arteaga C, Garza D, Tonstad S. Efficacy and safety of varenicline for smoking cessation in patients with cardiovascular disease: a randomized trial. Circulation. 2010;121:221–9.PubMedCrossRefGoogle Scholar
  30. 30.
    Stead LF, Perera R, Bullen C, Mant D, Lancaster T. Nicotine replacement therapy for smoking cessation (Cochrane Review). Cochrane Database Syst Rev. 2008.Google Scholar
  31. 31.
    Schnoll RA, Martinez E, Tatum KL, Glass M, Bernath A, Ferris D, et al. Nicotine patch vs. nicotine lozenge for smoking cessation: an effectiveness trial coordinated by the Community Clinical Oncology Program. Drug Alcohol Depend. 2010;107:237–43.PubMedCrossRefGoogle Scholar
  32. 32.
    Hammond D, Reid JL, Driezen P, Cummings KM, Borland R, Fong GT, et al. Smokers’ use of nicotine replacement therapy for reasons other than stopping smoking: findings from the ITC Four Country Survey. Addiction. 2008;103(10):1696–703.PubMedCrossRefGoogle Scholar
  33. 33.
    Langley TE, Huang Y, Lewis S, McNeill A, Coleman T, Szatkowski L. Prescribing of nicotine replacement therapy to adolescents in England. Addiction. 2011;106:1513–9.PubMedCrossRefGoogle Scholar
  34. 34.
    Shahab L, Cummings KM, Hammond D, Borland R, West R, McNeill A. The impact of changing nicotine replacement therapy licensing laws in the United Kingdom: findings from the International Tobacco Control Four Country Survey. Addiction. 2009;104:1420–7.PubMedCrossRefGoogle Scholar
  35. 35.
    McNeil A, Foulds J, Bates C. Regulation of nicotine replacement therapies (NRT): a critique of current practice. Addiction. 2001;96:1757–68.CrossRefGoogle Scholar
  36. 36.
    Shiffman S, Hughes JR. Improving on the proven: increased efficacy and reach with innovations in use of therapeutic nicotine. J Smok Cessat. 2009;4(Suppl 2):1–21.Google Scholar
  37. 37.
    Sweeney CT, Fant RV, Fagerstrom KO, McGovern JF, Henningfield JE. Combination nicotine replacement therapy for smoking cessation: rationale, efficacy and tolerability. CNS Drugs. 2001;15:453–67.PubMedCrossRefGoogle Scholar
  38. 38.
    Ingersoll KS, Cohen J. Combination treatment for nicotine dependence: state of the science. Subst Use Misuse. 2005;40:1923–2048.PubMedCrossRefGoogle Scholar
  39. 39.
    Shah SD, Wilken LA, Winkler SR, Lin SJ. Systematic review and meta-analysis of combination therapy for smoking cessation. J Am Pharm Assoc. 2008;48(5):659–65.CrossRefGoogle Scholar
  40. 40.
    Lumley J, Chamberlain C, Dowswell T, Oliver S, Oakley L, Watson L. Interventions for promoting smoking cessation during pregnancy (Review). The Cochrane Library 2009, Issue 9. Oxford: Wiley; 2009.Google Scholar
  41. 41.
    Coleman T, Chamberlain C, Davey MA, Cooper SE, Leonardi Bee J. Pharmacological interventions for promoting smoking cessation during pregnancy (Review). The Cochrane Library 2012, Issue 9. Oxford: Wiley; 2012.Google Scholar
  42. 42.
    Grimshaw G, Stanton A. Tobacco cessation interventions for young people (Review). Cochrane Library 2010, Issue 1. Oxford: Wiley; 2010.Google Scholar
  43. 43.
    Bailey SR, Crew EE, Riske EC, Ammerman S, Robinson TN, Killen JD. Efficacy and tolerability of pharmacotherapies to aid smoking cessation in adolescents. Paediatr Drugs. 2012;14(2):91–108.PubMedCrossRefGoogle Scholar
  44. 44.
    Molyneux A, Lewis S, Lewis S, Leivers U, Anderton A, Antoniak M, et al. Clinical trial comparing nicotine replacement therapy (NRT) plus brief counselling, brief counselling alone, and minimal intervention on smoking cessation in hospital inpatients. Thorax. 2003;58:484–8.PubMedCrossRefGoogle Scholar
  45. 45.
    Hughes JR, Keely JP, Niaura RS, Ossip-Klein DJ, Richmond RL, Swan GE. Measures of abstinence in clinical trials: Issues and recommendations. Nicotine Tob Res. 2003;5:13–25.PubMedGoogle Scholar
  46. 46.
    Hughes JR, Carpenter MJ, Naud S. Do point prevalence and prolonged abstinence measures produce similar results in smoking cessation studies? A systematic review. Nicotine Tob Res. 2010;12:756–62.PubMedCrossRefGoogle Scholar
  47. 47.
    Herrera N, Franco R, Herrera L, Partidas A, Rolando R, Fagerström K. Nicotine gum, 2 and 4 mg, for nicotine dependence: a double-blind placebo-controlled trial within a behavior modification support program. Chest. 1995;108:447–51.PubMedCrossRefGoogle Scholar
  48. 48.
    Bullen C, Howe C, Lin R-B, Grigg M, Laugesen M, McRobbie H, et al. Pre-cessation nicotine replacement therapy: pragmatic randomized trial. Addiction. 2010;105:1474–83.PubMedCrossRefGoogle Scholar
  49. 49.
    Schuurmans MM, Diacon AH, van Biljon X, Bolliger CT. Effect of pre-treatment with nicotine patch on withdrawal symptoms and abstinence rates in smokers subsequently quitting with the nicotine patch: a randomized controlled trial. Addiction. 2004;99:634–40.PubMedCrossRefGoogle Scholar
  50. 50.
    Rose JE, Behm FM, Westman EC, Kukovich P. Precessation treatment with nicotine skin patch facilitates smoking cessation. Nicotine Tob Res. 2006;8:89–101.PubMedCrossRefGoogle Scholar
  51. 51.
    Rose JE, Herskovic JE, Behm FM, Westman EC. Precessation treatment with nicotine patch significantly increases abstinence rates relative to conventional treatment. Nicotine Tob Res. 2009;11:1067–75.PubMedCrossRefGoogle Scholar
  52. 52.
    Rezaishiraz H, Hyland A, Mahoney MC, O’Connor RJ, Cummings KM. Treating smokers before the quit date: can nicotine patches and denicotinized cigarettes reduce cravings. Nicotine Tob Res. 2007;9:1139–46.PubMedCrossRefGoogle Scholar
  53. 53.
    Rose JE, Behm FM, Westman EC. Nicotine-mecamylamine treatment for smoking cessation: the role of pre-cessation therapy. Exp Clin Psychopharmacol. 1998;6(3):331–43.PubMedCrossRefGoogle Scholar
  54. 54.
    Etter JF, Huguelet P, Perneger TV, Cornuz J. Nicotine gum treatment before smoking cessation: a randomized trial. Arch Intern Med. 2009;169(11):1028–34.PubMedCrossRefGoogle Scholar
  55. 55.
    Hughes JR. Tobacco withdrawal in self-quitters. J Consult Clin Psychol. 1992;60:689–97.PubMedCrossRefGoogle Scholar
  56. 56.
    Hughes JR. Craving among long-abstinent smokers: an internet survey. Nicotine Tob Res. 2010;12:459–62.PubMedCrossRefGoogle Scholar
  57. 57.
    Hughes JR, Keely JP, Naud S. Shape of relapse curve and long-term abstinence among untreated smokers. Addiction. 2004;99:29–38.PubMedCrossRefGoogle Scholar
  58. 58.
    Hughes JR, Gust SW, Keenan R, Fenwick JW, Skoog K, Higgins ST. Long-term use of nicotine vs placebo gum. Arch Intern Med. 1991;151(10):1993–8.PubMedCrossRefGoogle Scholar
  59. 59.
    Oncken C, Cooney J, Feinn R, Lando H, Kranzler HR. Transdermal nicotine for smoking cessation in postmenopausal women. Addict Behav. 2007;32(2):296–309.PubMedCrossRefGoogle Scholar
  60. 60.
    Sachs DP, Sawe U, Leischow SJ. Effectiveness of a 16-hour transdermal nicotine patch in a medical practice setting, without intensive group counseling. Arch Intern Med. 1993;153(16):1881–90.PubMedCrossRefGoogle Scholar
  61. 61.
    Tonnesen P, Norregaard J, Mikkelsen K, Jorgensen S, Nilsson F. A double-blind trial of a nicotine inhaler for smoking cessation. JAMA. 1993;269(10):1268–71.PubMedCrossRefGoogle Scholar
  62. 62.
    Stapleton JA, Russell MA, Feyerabend C, Wiseman SM, Gustavsson G, Sawe U, et al. Dose effects and predictors of outcome in a randomized trial of transdermal nicotine patches in general practice. Addiction. 1995;90(1):31–42.PubMedCrossRefGoogle Scholar
  63. 63.
    Pomerleau OF, Pomerleau CS, Marks JL, Snedecor SM, Mehringer AM, Namenek Brouwer RJ, et al. Prolonged nicotine patch use in quitters with past abstinence-induced depressed mood. J Subst Abuse Treat. 2003;24(1):13–8.PubMedCrossRefGoogle Scholar
  64. 64.
    Schnoll RA, Patterson F, Wileyto EP, Heitjan DF, Shields AE, Asch DA, et al. Effectiveness of extended-duration transdermal nicotine therapy: a randomized trial. Ann Intern Med. 2010;152:144–51.PubMedCrossRefGoogle Scholar
  65. 65.
    Tonnesen P, Paoletti P, Gustavsson G, Russell MA, Saracci R, Gulsvik A, et al. Higher dosage nicotine patches increase one-year smoking cessation rates: results from the European CEASE trial. Collaborative European Anti-Smoking Evaluation. European Respiratory Society. Eur Respir J. 1999;13(2):238–46.PubMedCrossRefGoogle Scholar
  66. 66.
    Hall SM, Humfleet GL, Muñoz RF, Reus VI, Robbins JA, Prochaska JJ. Extended treatment of older cigarette smokers. Addiction. 2009;104:1043–52.PubMedCrossRefGoogle Scholar
  67. 67.
    Joseph AM, Fu SS, Lindgren B, Rothman AJ, Kodl M, Lando H, et al. Chronic disease management for tobacco dependence: a randomized, controlled trial. Arch Intern Med. 2011;171:1894–900.PubMedCrossRefGoogle Scholar
  68. 68.
    Shiffman S, Ferguson SG, Gwaltney CJ, Balabanis MH, Shadel WG. Reduction of abstinence-induced withdrawal and craving using high-dose nicotine replacement therapy. Psychopharmacology (Berl). 2006;184:637–44.CrossRefGoogle Scholar
  69. 69.
    Hatsukami DK, Mooney M, Murphy S, LeSage M, Babb D, Hecht S. Effects of high dose transdermal nicotine replacement in cigarette smokers. Pharmacol Biochem Behav. 2007;86:132–9.PubMedCrossRefGoogle Scholar
  70. 70.
    Ferguson SG, Shiffman S, Gwaltney CJ. Does reducing withdrawal severity mediate nicotine patch efficacy? A randomized clinical trial. J Consult Clin Psychol. 2006;74(6):1153–61.PubMedCrossRefGoogle Scholar
  71. 71.
    Schnoll RA, Wileyto EP, Leone FT, Tyndale RF, Benowitz NL. High dose transdermal nicotine for fast metabolizers of nicotine: a proof of concept placebo-controlled trial. Nicotine Tob Res. 2013;15:348–54.PubMedCrossRefGoogle Scholar
  72. 72.
    Dale LC, Hurt RD, Offord KP, Lawson GM, Croghan IT, Schroeder DR. High-dose nicotine patch therapy. Percentage of replacement and smoking cessation. JAMA. 1995;274(17):1353–8.PubMedCrossRefGoogle Scholar
  73. 73.
    Jorenby DE, Smith SS, Fiore MC, Hurt RD, Offord KP, Croghan IT, et al. Varying nicotine patch dose and type of smoking cessation counseling. JAMA. 1995;274(17):1347–52.PubMedCrossRefGoogle Scholar
  74. 74.
    Kalman D, Kahler CW, Garvey AJ, Monti PM. High-dose nicotine patch therapy for smokers with a history of alcohol dependence: 36-week outcomes. J Subst Abuse Treat. 2006;30(3):213–7.PubMedCrossRefGoogle Scholar
  75. 75.
    Hughes JR, Lesmes GR, Hatsukami DK, Richmond RL, Lichtenstein E, Jorenby DE, et al. Are higher doses of nicotine replacement more effective for smoking cessation? Nicotine Tob Res. 1999;1(2):169–74.PubMedCrossRefGoogle Scholar
  76. 76.
    Killen JD, Fortmann SP, Davis L, Strausberg L, Varady A. Do heavy smokers benefit from higher dose nicotine patch therapy? Exp Clin Psychopharmacol. 1999;7(3):226–33.PubMedCrossRefGoogle Scholar
  77. 77.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol Med. 2010;16(7–8):247–53.PubMedGoogle Scholar
  78. 78.
    Paoletti P, Fornai E, Maggiorelli F, Puntoni R, Viegi G, Carrozzi L, et al. Importance of baseline cotinine plasma values in smoking cessation: results from a double-blind study with nicotine patch. Eur Respir J. 1996;9(4):643–51.PubMedCrossRefGoogle Scholar
  79. 79.
    Henningfield JE, Fant RV, Buchhalter AR, Stitzer ML. Pharmacotherapy for nicotine dependence. Cancer. 2005;55:281–99.Google Scholar
  80. 80.
    Shiffman S, Shadel WG, Niaura R, Khayrallah MA, Jorenby DE, Ryan CF, et al. Efficacy of acute administration of nicotine gum in relief of cue-provoked cigarette craving. Psychopharmacology (Berl). 2003;166:343–50.Google Scholar
  81. 81.
    Tiffany ST, Wray JM. The clinical significance of drug craving. Ann N Y Acad Sci. 2012;1248:1–17.PubMedCrossRefGoogle Scholar
  82. 82.
    Fagerstrom KO, Schneider NG, Lunell E. Effectiveness of nicotine patch and nicotine gum as individual versus combined treatments for tobacco withdrawal symptoms. Psychopharmacology (Berl). 1993;111(3):271–7.CrossRefGoogle Scholar
  83. 83.
    Schneider NG, Cortner C, Gould JL, Koury MA, Olmstead R. Comparison of craving and withdrawal among four combination nicotine treatments. Hum Psychopharmacol Clin Exp. 2008;23:513–7.CrossRefGoogle Scholar
  84. 84.
    Schneider NG, Cortner C, Justice M, Gould JL, Amor C, Hartman N, et al. Preferences among five nicotine treatments based on information versus sampling. Nicotine Tob Res. 2008;10:179–86.PubMedCrossRefGoogle Scholar
  85. 85.
    Schneider NG, Koury MA, Cortner C, Olmstead RE, Hartman N, Kleinman L, et al. Preferences among four combination nicotine treatments. Psychopharmacology (Berl). 2006;187(4):476–85.CrossRefGoogle Scholar
  86. 86.
    Perkins KA, Lerman C, Keenan J, Fonte C, Coddington S. Rate of nicotine onset from nicotine replacement therapy and acute responses in smokers. Nicotine Tob Res. 2004;6:501–7.PubMedCrossRefGoogle Scholar
  87. 87.
    Hand S, Edwards S, Campbell IA, Cannings R. Controlled trial of three weeks nicotine replacement treatment in hospital patients also given advice and support. Thorax. 2002;57:715–8.PubMedCrossRefGoogle Scholar
  88. 88.
    Steinberg MB, Greenhaus S, Schmelzer AC, Bover MT, Foulds J, Hoover DR, et al. Triple-combination pharmacotherapy for medically ill smokers: a randomized trial. Ann Intern Med. 2009;150:447–54.PubMedCrossRefGoogle Scholar
  89. 89.
    Piper ME, Smith SS, Schlam TR, Fiore MC, Jorenby DE, Fraser D, et al. A randomized placebo-controlled clinical trial of 5 smoking cessation pharmacotherapies. Arch Gen Psychiatry. 2009;66:1253–62.PubMedCrossRefGoogle Scholar
  90. 90.
    Smith SS, McCarthy DE, Japuntich SJ, Christiansen B, Piper ME, Jorenby DE, et al. Comparative effectiveness of five smoking cessation pharmacotherapies in primary care clinics. Arch Intern Med. 2009;14:2148–55.CrossRefGoogle Scholar
  91. 91.
    Bolt DM, Piper ME, Theobald WE, Baker TB. Why two smoking cessation agents work better than one: role of craving suppression. J Consult Clin Psychol. 2012;80(1):54–65.PubMedCrossRefGoogle Scholar
  92. 92.
    Puska P, Korhonen HJ, Vartiainen V, Urjanheimo E, Gustavsson G, Westin A. Combined use of nicotine patch and gum compared with gum alone in smoking cessation: a clinical trial in North Karelia. Tob Control. 1995;4:231–5.CrossRefGoogle Scholar
  93. 93.
    Kornitzer M, Boutsen M, Dramaix M, Thijs J, Gustavsson G. Combined use of nicotine patch and gum in smoking cessation: a placebo-controlled clinical trial. Prev Med. 1995;24(1):41–7.PubMedCrossRefGoogle Scholar
  94. 94.
    Cooney NL, Cooney JL, Perry BL, Carbone M, Cohen EH, Steinberg HR, et al. Smoking cessation during alcohol treatment: a randomized trial of combination nicotine patch plus nicotine gum. Addiction. 2009;104(9):1588–96.PubMedCrossRefGoogle Scholar
  95. 95.
    Blondal T, Gudmundsson LJ, Olafsdottir I, Gustavsson G, Westin A. Nicotine nasal spray with nicotine patch for smoking cessation: randomised trial with six year follow up. BMJ. 1999;318:285–8.PubMedCrossRefGoogle Scholar
  96. 96.
    Croghan GA, Sloan JA, Croghan IT, Novotny P, Hurt RD, DeKrey WL, et al. Comparison of nicotine patch alone versus nicotine nasal spray alone versus a combination for treating smokers: a minimal intervention, randomized multicenter trial in a nonspecialized setting. Nicotine Tob Res. 2003;5:181–7.PubMedCrossRefGoogle Scholar
  97. 97.
    Bohadana A, Nilsson F, Rasmussen T, Martinet Y. Nicotine inhaler and nicotine patch as a combination therapy for smoking cessation: a randomized, double-blind, placebo-controlled trial. Arch Intern Med. 2000;160(20):3128–34.PubMedCrossRefGoogle Scholar
  98. 98.
    Tonnesen P, Mikkelsen KL. Smoking cessation with four nicotine replacement regimes in a lung clinic. Eur Respir J. 2000;16(4):717–22.PubMedCrossRefGoogle Scholar
  99. 99.
    Kalman D, Tirch D, Kahler C, Penk W, Kaschub C, Monti PM. Twelve-week outcomes from an investigation of high dose nicotine patch therapy for heavy smokers with a past history of alcohol dependence. Psychol Addict Behav. 2004;18:78–82.PubMedCrossRefGoogle Scholar
  100. 100.
    West R, Hajek P, Foulds J, Nilsson F, Burrows S, Meadows A. A comparison of the abuse liability and dependence potential of nicotine patch, gum, spray and inhaler. Psychopharmacology (Berl). 2000;149:198–202.CrossRefGoogle Scholar
  101. 101.
    Benowitz NL. Nicotine safety and toxicity. New York: Oxford University Press; 1998.Google Scholar
  102. 102.
    Hughes JR, Pillitteri JL, Callas PW, Calahan R, Kenny M. Misuse of and dependence on over-the-counter nicotine gum in a volunteer sample. Nicotine Tob Res. 2004;6:79–84.PubMedCrossRefGoogle Scholar
  103. 103.
    Yudkin PL, Jones L, Lancaster T, Fowler GH. Which smokers are helped to give up smoking using transdermal nicotine patches? Results from a randomized, double-blind, placebo-controlled trial. Br J Gen Pract. 1996;46(404):145–8.PubMedGoogle Scholar
  104. 104.
    Fagerstrom KO, Schneider NG. Measuring nicotine dependence: a review of the Fagerstrom Tolerance Questionnaire. J Behav Med. 1989;12(2):159–82.PubMedCrossRefGoogle Scholar
  105. 105.
    Kortmann GL, Dobler CJ, Bizarro L, Bau CH. Pharmacogenetics of smoking cessation therapy. Am J Med Genet. 2010;153B(1):17–28.PubMedGoogle Scholar
  106. 106.
    Lerman CE, Schnoll RA, Munafò MR. Genetics and smoking cessation: improving outcomes in smokers at risk. Am J Prev Med. 2007;33:S398–405.PubMedCrossRefGoogle Scholar
  107. 107.
    Munafo MR, Johnstone EC, Walther D, Uhl GR, Murphy MF, Aveyard P. CHRNA3 rs1051730 genotype and short-term smoking cessation. Nicotine Tob Res. 2011;13(10):982–8.PubMedCrossRefGoogle Scholar
  108. 108.
    Gold AB, Wileyto EP, Lori A, Conti D, Cubells JF, Lerman C. Pharmacogenetic association of the galanin receptor (GALR1) SNP rs2717162 with smoking cessation. Neuropsychopharmacology. 2012;37:1683–8.PubMedCrossRefGoogle Scholar
  109. 109.
    Lee AM, Jepson C, Shields PG, Benowitz N, Lerman C, Tyndale RF. CYP2B6 genotype does not alter nicotine metabolism, plasma levels, or abstinence with nicotine replacement therapy. Cancer Epidemiol Biomarkers Prev. 2007;16(6):1312–4.PubMedCrossRefGoogle Scholar
  110. 110.
    Garvey AJ, Kinnunen T, Nordstrom BL, Utman CH, Doherty K, Rosner B, et al. Effects of nicotine gum dose by level of nicotine dependence. Nicotine Tob Res. 2000;2:53–63.PubMedCrossRefGoogle Scholar
  111. 111.
    Niaura R, Goldstein MG, Abrams DB. Matching high- and low-dependence smokers to self-help treatment with or without nicotine replacement. Prev Med. 1994;23(1):70–7.PubMedCrossRefGoogle Scholar
  112. 112.
    Tonnesen P, Fryd V, Hansen M, Helsted J, Gunnersen AB, Forchammer H, et al. Effect of nicotine chewing gum in combination with group counseling on the cessation of smoking. N Engl J Med. 1988;318(1):15–8.PubMedCrossRefGoogle Scholar
  113. 113.
    Schnoll RA, Patterson F, Wileyto EP, Tyndale RF, Benowitz N, Lerman C. Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study. Pharmacol Biochem Behav. 2009;92:6–11.PubMedCrossRefGoogle Scholar
  114. 114.
    Lerman C, Tyndale R, Patterson F, Wileyto EP, Shields PG, Pinto A, et al. Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation. Clin Pharmacol Ther. 2006;79(6):600–8.PubMedCrossRefGoogle Scholar
  115. 115.
    Marteau TM, Aveyard P, Munafo MR, Prevost AT, Hollands GJ, Armstrong D, et al. Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial. PLoS ONE. 2012;7(4):e35249.PubMedCrossRefGoogle Scholar
  116. 116.
    Abrams DB, Orleans CT, Niaura RS, Goldstein MG, Prochaska JO, Velicer W. Integrating individual and public health perspectives for treatment of tobacco dependence under managed health care: a combined stepped-care and matching model. Ann Behav Med. 1996;18:290–304.PubMedCrossRefGoogle Scholar
  117. 117.
    Japuntich SJ, Piper ME, Leventhal AM, Bolt DM, Baker TB. The effect of five smoking cessation pharmacotherapies on smoking cessation milestones. J Consult Clin Psychol. 2011;79:34–42.PubMedCrossRefGoogle Scholar
  118. 118.
    Shiffman S, Scharf DM, Shadel WG, Gwaltney CJ, Dang Q, Paton SM, et al. Analyzing milestones in smoking cessation: illustration in a nicotine patch trial in adult smokers. J Consult Clin Psychol. 2006;74(2):276–85.PubMedCrossRefGoogle Scholar
  119. 119.
    Shiffman S, Ferguson SG, Gwaltney CJ. Immediate hedonic response to smoking lapses: relationship to smoking relapse, and effects of nicotine replacement therapy. Psychopharmacology (Berl). 2006;184(3–4):608–18.CrossRefGoogle Scholar
  120. 120.
    Agboola S, McNeill A, Coleman T, Bee JL. A systematic review of the effectiveness of smoking relapse prevention interventions for abstinent smokers. Addiction. 2010;105:1362–80.PubMedCrossRefGoogle Scholar
  121. 121.
    Hajek P, Stead LF, West R, Jarvis M, Lancaster T. Relapse prevention interventions for smoking cessation (Review). The Cochrane Library 2009.Google Scholar
  122. 122.
    Covey LS, Glassman AH, Jiang H, Fried J, Masmela J, LoDuca C, et al. A randomized trial of bupropion and/or nicotine gum as maintenance treatment for preventing smoking relapse. Addiction. 2007;102:1292–302.PubMedCrossRefGoogle Scholar
  123. 123.
    Croghan IT, Hurt RD, Dakhil SR, Croghan GA, Sloan JA, Novotny PJ, et al. Randomized comparison of a nicotine inhaler and bupropion for smoking cessation and relapse prevention. Mayo Clin Proc. 2007;82(2):186–95.PubMedGoogle Scholar
  124. 124.
    Fortmann SP, Killen JD. Nicotine gum and self-help behavioral treatment for smoking relapse prevention: results from a trial using population-based recruitment. J Consult Clin Psychol. 1995;63(3):460–8.PubMedCrossRefGoogle Scholar
  125. 125.
    Killen JD, Fortmann SP, Newman B, Varady A. Evaluation of a treatment approach combining nicotine gum with self-guided behavioral treatments for smoking relapse prevention. J Consult Clin Psychol. 1990;60:586–94.Google Scholar
  126. 126.
    Ahmadi J, Ashkani H, Ahmadi M, Ahmadi N. Twenty-four week maintenance treatment of cigarette smoking with nicotine gum, clonidine and naltrexone. J Subst Abuse Treat. 2003;24(3):251–5.PubMedCrossRefGoogle Scholar
  127. 127.
    Schroter M, Collins SE, Frittrang T, Buchkremer G, Batra A. Randomized controlled trial of relapse prevention and a standard behavioral intervention with adult smokers. Addict Behav. 2006;31(7):1259–64.PubMedCrossRefGoogle Scholar
  128. 128.
    Stein MD, Anderson BJ, Niaura R. Nicotine replacement therapy: patterns of use after a quit attempt among methadone-maintained smokers. J Gen Intern Med. 2006;21(7):753–7.PubMedCrossRefGoogle Scholar
  129. 129.
    Wetter DW, McClure JB, Cofta-Woerpel L, Costello TJ, Reitzel LR, Businelle MS, et al. A randomized clinical trial of a palmtop computer-delivered treatment for smoking relapse prevention among women. Psychol Addict Behav. 2011;25(2):365–71.PubMedCrossRefGoogle Scholar
  130. 130.
    Shiffman S, Khayrallah M, Nowak R. Efficacy of the nicotine patch for relief of craving and withdrawal 7–10 weeks after cessation. Nicotine Tob Res. 2000;2:371–8.PubMedCrossRefGoogle Scholar
  131. 131.
    Tiffany S, Cox LS, Elash CA. Effects of transdermal nicotine patches on abstinence-induced and cue-elicited craving in cigarette smokers. J Consult Clin Psychol. 2000;68:233–40.PubMedCrossRefGoogle Scholar
  132. 132.
    Waters AJ, Shiffman S, Sayette MA, Paty JA, Gwaltney CJ, Balabanis MH. Cue-provoked craving and nicotine replacement therapy in smoking cessation. J Consult Clin Psychol. 2004;72:1136–43.PubMedCrossRefGoogle Scholar
  133. 133.
    Foulds J. Use of nicotine replacement therapy to treat nicotine withdrawal syndrome and aid temporary abstinence. Int J Clin Pract. 2010;64:292–4.PubMedCrossRefGoogle Scholar
  134. 134.
    Schmidt CW. A change in the air: smoking bans gain momentum worldwide. Environ Health Perspect. 2007;115:A412–5.PubMedCrossRefGoogle Scholar
  135. 135.
    Borland R, Yong HH, Cummings KM, Hyland A, Anderson S, Fong GT. Determinants and consequences of smoke-free homes: findings from the International Tobacco Control (ITC) Four Country Survey. Tob Control. 2006;15(Suppl 3):iii42–50.PubMedCrossRefGoogle Scholar
  136. 136.
    Smoke Free Partnership. The Smokefree Mapp. 2012. http://smokefreepartnership.eu/smokefreemap (Accessed March 11 2013).
  137. 137.
    Americans for Nonsmokers’ Rights. 2013. http://www.no-smoke.org/aboutus.php?id=436 (Accessed March 11 2013).
  138. 138.
    USDHS. The health consequences of involuntary exposure to tobacco smoke: a report of the surgeon general. Washington DC: US Govt. Printing Office; 2006.Google Scholar
  139. 139.
    Jones TE, Williams J. Craving control using nicotine replacement therapy in a teaching hospital. Intern Med. 2012;42:317–22.CrossRefGoogle Scholar
  140. 140.
    Levy DE, Thorndike AN, Biener L, Rigotti NA. Use of nicotine replacement therapy to reduce or delay smoking but not to quit: prevalence and association with subsequent cessation efforts. Tob Control. 2007;16(6):384–9.PubMedCrossRefGoogle Scholar
  141. 141.
    Beard E, West R. Use of nicotine replacement therapy for smoking reduction and temporary abstinence: an update of Beard et al. (2011). Addiction. 2012;107:1186–7.PubMedCrossRefGoogle Scholar
  142. 142.
    Beard E, McNeill A, Aveyard P, Fidler J, Michie S, West R. Use of nicotine replacement therapy for smoking reduction and during enforced temporary abstinence: a national survey of English smokers. Addiction. 2011;106:197–204.PubMedCrossRefGoogle Scholar
  143. 143.
    Center for Disease Control and Prevention. Smoking and tobacco use. 2013. http://www.cdc.gov/tobacco/data_statistics/fact_sheets/cessation/quitting/index.htm (Accessed January 13 2013).
  144. 144.
    Wewers ME, Stillman FA, Hartman AM, Shopland DR. Distribution of daily smokers by stage of change: current population survey results. Prev Med. 2003;36:710–20.PubMedCrossRefGoogle Scholar
  145. 145.
    Etter JF. Comparing abrupt and gradual smoking cessation: a randomized trial. Drug Alcohol Depend. 2011;118:360–5.PubMedCrossRefGoogle Scholar
  146. 146.
    Hughes JR, Solomon LJ, Livingston AE, Callas PW, Peters EN. A randomized, controlled trial of NRT-aided gradual vs. abrupt cessation in smokers actively trying to quit. Drug Alcohol Depend. 2010;111:105–13.PubMedCrossRefGoogle Scholar
  147. 147.
    Batra A, Klingler K, Landfeldt B, Friederich HM, Westin A, Danielsson T. Smoking reduction treatment with 4-mg nicotine gum: a double-blind, randomized placebo-controlled study. Clin Pharmacol Ther. 2005;78:689–96.PubMedCrossRefGoogle Scholar
  148. 148.
    Etter JF, Laszlo E. Postintervention effect of nicotine replacement therapy for smoking reduction: a randomized trial with a 5-year follow-up. J Clin Psychopharmacol. 2007;27:151–5.PubMedCrossRefGoogle Scholar
  149. 149.
    Etter JF, Laszlo E, Perneger TV. Post-intervention effect of nicotine replacement therapy on smoking reduction in smokers who are unwilling to quit: a randomized trial. J Clin Psychopharmacol. 2004;24:174–9.PubMedCrossRefGoogle Scholar
  150. 150.
    Rennard SI, Glover ED, Leischow S, Daughton DM, Glover PN, Muramoto M, et al. Efficacy of the nicotine inhaler in smoking reduction: a double-blind, randomized trial. Nicotine Tob Res. 2006;8:555–64.PubMedCrossRefGoogle Scholar
  151. 151.
    Wennike P, Danielsson T, Landeck BF, Westin A, Tonnesen P. Smoking reduction promotes smoking cessation. Results from a double blind, randomised, placebo-controlled trial of nicotine gum with 2-year follow-up. Addiction. 2003;98:1395–402.PubMedCrossRefGoogle Scholar
  152. 152.
    Carpenter MJ, Hughes JR, Keely JP. Effect of smoking reduction on later cessation: a pilot experimental study. Nicotine Tob Res. 2003;5:155–62.PubMedCrossRefGoogle Scholar
  153. 153.
    Joseph AM, Hecht SS, Murphy SE, Lando H, Carmella SG, Gross M, et al. Smoking reduction fails to improve clinical and biological markers of cardiac disease: a randomized controlled trial. Nicotine Tob Res. 2008;10:471–81.PubMedCrossRefGoogle Scholar
  154. 154.
    Tonnesen P, Pisinger C, Hvidberg S, Wennike P, Bremann L, Westin A, et al. Effects of smoking cessation and reduction in asthmatics. Nicotine Tob Res. 2005;7:139–48.PubMedCrossRefGoogle Scholar
  155. 155.
    Chan SSC, Leung DYP, Abdullah ASM, Wong VT, Hedley AJ, Lam T-H. A randomised controlled trial of a smoking reduction plus nicotine replacement therapy intervention for smokers not willing to quit smoking. Addiction. 2011;106(6):1155–63.PubMedCrossRefGoogle Scholar
  156. 156.
    Asfar T, Ebbert JO, Klesges RC, Relyea GE. Do smoking reduction interventions promote cessation in smokers not ready to quit? Addict Behav. 2011;36:764–8.PubMedCrossRefGoogle Scholar
  157. 157.
    Hatsukami DK, Perkins KA, Lesage MG, Ashley DL, Henningfield JE, Benowitz NL, et al. Nicotine reduction revisited: science and future directions. Tob Control. 2010;19(5):e1–10.PubMedCrossRefGoogle Scholar
  158. 158.
    Hughes JR. Reduced smoking: an introduction and review of the evidence. Addiction. 2000;95:S3–8.PubMedGoogle Scholar
  159. 159.
    Hughes JR, Carpenter MJ. The feasibility of smoking reduction: an update. Addiction. 2005;100:1074–89.PubMedCrossRefGoogle Scholar
  160. 160.
    Stead LF, Lancaster T. Interventions to reduce harm from continued tobacco use (Cochrane Review). The Cochrane Library, Issue 3. Oxford: Updated Software; 2007.Google Scholar
  161. 161.
    Moore D, Aveyard P, Connock M, Wang D, Fry-Smith A, Barton P. Effectiveness and safety of nicotine replacement therapy assisted reduction to stop smoking: systematic review and meta-analysis. Br Med J. 2009;338:b1024.CrossRefGoogle Scholar
  162. 162.
    Wang D, Connock M, Barton P, Fry-Smith A, Aveyard P, Moore D. ‘Cut down to quit’ with nicotine replacement therapies in smoking cessation: a systematic review of effectiveness and economic analysis. Health Technol Assess. 2008;12(2):iii–iv, ix–xi, 1–135.Google Scholar
  163. 163.
    Fagerstrom K-O, Tejding R, Ake W, Lunell E. Aiding reduction of smoking with nicotine replacement medications. Hope for the recalcitrant smoker? Tob Control. 1997;6:311–6.PubMedCrossRefGoogle Scholar
  164. 164.
    Jolicoeur DG, Richter KP, Ahluwalia JS, Mosier MC, Resnicow K. Smoking cessation, smoking reduction, and delayed quitting among smokers given nicotine patches and a self-help pamphlet. Subst Abuse. 2003;24:101–6.Google Scholar
  165. 165.
    Shahab L, McEwen A, West R. Acceptability and effectiveness for withdrawal symptom relief of a novel oral nicotine delivery device: a randomised crossover trial. Psychopharmacology (Berl). 2011;216:187–96.CrossRefGoogle Scholar
  166. 166.
    Rose JE, Turner JE, Murugesan T, Behm FM, Laugesen M. Pulmonary delivery of nicotine pyruvate: sensory and pharmacokinetic characteristics. Exp Clin Psychopharmacol. 2010;18:385–94.PubMedCrossRefGoogle Scholar
  167. 167.
    Thornley S, McRobbie H, Lin R, Bullen C, Hajek P, Laugesen M, et al. A single-blind, randomized, crossover trial of the effects of a nicotine pouch on the relief of tobacco withdrawal symptoms and user satisfaction. Nicotine Tob Res. 2009;11:715–21.PubMedCrossRefGoogle Scholar
  168. 168.
    Shiffman S, Cone EJ, Buchhalter AR, Henningfield JE, Rohay JM, Gitchell JG, et al. Rapid absorption of nicotine from new nicotine gum formulations. Pharmacol Biochem Behav. 2009;91:380–4.PubMedCrossRefGoogle Scholar
  169. 169.
    Hansson A, Hajek P, Perfekt R, Kraiczi H. Effects of nicotine mouth spray on urges to smoke, a randomised clinical trial. BMJ Open. 2012;2:e001618.PubMedCrossRefGoogle Scholar
  170. 170.
    McRobbie H, Thornley S, Bullen C, Lin RB, Senior H, Laugesen M, et al. A randomized trial of the effects of two novel nicotine replacement therapies on tobacco withdrawal symptoms and user satisfaction. Addiction. 2010;105(7):1290–8.PubMedCrossRefGoogle Scholar
  171. 171.
    Tønnesen P, Lauri H, Perfekt R, Mann K, Batra A. Efficacy of a nicotine mouth spray in smoking cessation: a randomised, double-blind trial. Eur Respir J. 2012;40:548–54.PubMedCrossRefGoogle Scholar
  172. 172.
    Bolliger CT, van Biljon X, Axelsson A. A nicotine mouth spray for smoking cessation: a pilot study of preference, safety and efficacy. Respiration. 2007;74:196–201.PubMedCrossRefGoogle Scholar
  173. 173.
    Hughes JR, Adams EH, Franzon MA, Maguire MK, Guary J. A prospective study of off-label use of, abuse of and dependence on nicotine inhaler. Tob Control. 2005;14:49–54.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Matthew J. Carpenter
    • 1
    • 2
    • 5
  • Bianca F. Jardin
    • 1
    • 2
  • Jessica L. Burris
    • 1
    • 2
  • Amanda R. Mathew
    • 1
  • Robert A. Schnoll
    • 3
  • Nancy A. Rigotti
    • 4
  • K. Michael Cummings
    • 1
    • 2
  1. 1.Department of Psychiatry and Behavioral SciencesMedical University of South Carolina (MUSC)CharlestonUSA
  2. 2.MUSC Hollings Cancer CenterCharlestonUSA
  3. 3.Department of PsychiatryUniversity of PennsylvaniaPhiladelphiaUSA
  4. 4.Department of Medicine, Harvard Medical SchoolTobacco Research and Treatment CenterBostonUSA
  5. 5.Department of Psychiatry, Clinical Neuroscience, Hollings Cancer CenterMedical University of South CarolinaCharlestonUSA

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