CNS Drugs

, Volume 32, Issue 6, pp 559–565 | Cite as

Tailoring Treatment in Polymorbid Migraine Patients through Personalized Medicine

  • Leda Marina Pomes
  • Giovanna Gentile
  • Maurizio Simmaco
  • Marina Borro
  • Paolo Martelletti

Polytherapy in Migraine

Headache disorders represent the most frequent clinical problem among neurological diseases [1]. Migraine alone affects nearly 14% of the global population, and is the first cause of disability in people under 50 years of age, representing a real challenge for healthcare systems [2]. Evidence of multiple comorbidities in the migraine population, especially at cardio-cerebrovascular, psychiatric, metabolic, and musculoskeletal levels, has led to an observed increase in clinical practice of patients undergoing multiple pharmacological therapies [3, 4, 5, 6]. The use of different drugs in the same migraine patient significantly increases the risk of potentially serious adverse events (AEs) [7]. As a consequence, the development and implementation of precision medicine in clinical practice addresses this increased clinical risk, allowing advanced and early evaluation of possible drug–drug interactions (DDIs), and guiding clinical prescription and monitoring [7]. We...


Compliance with Ethical Standards


This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical statement

All the described procedures are conducted in compliance with the latest version of the Declaration of Helsinki and according to clinical guidelines.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Residency Program in Laboratory MedicineGabriele d’Annunzio UniversityChietiItaly
  2. 2.Department of Neurosciences, Mental Health and Sensory OrgansSapienza UniversityRomeItaly
  3. 3.Department of Clinical and Molecular MedicineSapienza University of RomeRomeItaly
  4. 4.Internal Medicine and Emergency Medicine UnitSant’Andrea HospitalRomeItaly
  5. 5.Regional Referral Headache CenterSant’Andrea HospitalRomeItaly

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