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Clinical Pharmacokinetics

, Volume 57, Issue 11, pp 1471–1472 | Cite as

Comment on “Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials”

  • Joseph F. Standing
  • Brian J. Anderson
  • Stefanie Hennig
  • Nick H. Holford
  • Trevor N. Johnston
  • Catherijne A. J. Knibbe
  • Dagan O. Lonsdale
  • Amin Rostami-Hodjegan
Letter to the Editor

Notes

Compliance with Ethical Standards

Funding

No external funding was used in the preparation of this letter.

Conflict of interest

Joseph F. Standing, Brian J. Anderson, Stefanie Hennig, Nick H. Holford, Trevor Johnston, Catherjine A.J. Knibbe, Dagan O. Lonsdale and Amin Rostami-Hodjegan declare that they have no conflicts of interest that might be relevant to the contents of this letter.

References

  1. 1.
    van Dijkman SC, de Jager NCB, Rauwe WM, Danhof M, Della Pasqua O. Effect of age-related factors on the pharmacokinetics of lamotrigine and potential implications for maintenance dose optimisation in future clinical trials. Clin Pharmacokinet. 2018.  https://doi.org/10.1007/s40262-017-0614-5.CrossRefPubMedGoogle Scholar
  2. 2.
    van Dijkman SC, de Jager NCB, Rauwe WM, Danhof M, Della Pasqua O. Correction to: effect of age-related factors on the pharmacokinetics of lamotrigine and potential implications for maintenance dose optimisation in future clinical trials. Clin Pharmacokinet. 2018.  https://doi.org/10.1007/s40262-018-0660-7.CrossRefPubMedGoogle Scholar
  3. 3.
    Sumpter AL, Holford NH. Predicting weight using postmenstrual age—neonates to adults. Paediatr Anaesth. 2011;21:309–15.CrossRefPubMedGoogle Scholar
  4. 4.
    Wang C, Peeters MY, Allegaert K, Blussé van Oud-Alblas HJ, Krekels EH, Tibboel D, et al. A bodyweight-dependent allometric exponent for scaling clearance across the human life-span. Pharm Res. 2012;29:1570–81.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Lonsdale DO, Kipper K, Barker C, Johnston A, Philips B, Rhodes A, et al. Standard beta–lactam doses fail to achieve PK/PD targets in critically ill patients of all ages, with children particularly at risk: results from the ABDose study [poster no. O0808]. 28th ECCMID (European Congress of Clinical Microbiology and Infectious Diseases) Meeting; 21–24 Apr 2018; Madrid.Google Scholar
  6. 6.
    Hennig S, Standing JF, Staatz CE, Thomson AH. Population pharmacokinetics of tobramycin in patients with and without cystic fibrosis. Clin Pharmacokinet. 2013;52:289–301.CrossRefPubMedGoogle Scholar
  7. 7.
    McCune JS, Bemer MJ, Barrett JS, Scott Baker K, Gamis AS, Holford NH. Busulfan in infant to adult hematopoietic cell transplant recipients: a population pharmacokinetic model for initial and Bayesian dose personalization. Clin Cancer Res. 2014;20:754–63.CrossRefPubMedGoogle Scholar
  8. 8.
    Holford NH, Ma SC, Anderson BJ. Prediction of morphine dose in humans. Paediatr Anaesth. 2012;22:209–22.CrossRefPubMedGoogle Scholar
  9. 9.
    Calvier EA, Krekels EH, Välitalo PA, Rostami-Hodjegan A, Tibboel D, Danhof M, et al. Allometric scaling of clearance in paediatric patients: when does the magic of 0.75 fade? Clin Pharmacokinet. 2017;56:273–85.CrossRefPubMedGoogle Scholar
  10. 10.
    Holford N, Heo YA, Anderson B. A pharmacokinetic standard for babies and adults. J Pharm Sci. 2013;102:2941–52.CrossRefGoogle Scholar
  11. 11.
    Germovsek E, Barker CI, Sharland M, Standing JF. Scaling clearance in paediatric pharmacokinetics: all models are wrong, which are useful? Br J Clin Pharmacol. 2017;83:777–90.CrossRefPubMedGoogle Scholar
  12. 12.
    Polepally AR, Remmel RP, Brundage RC, Leppik IE, Rarick JO, Ramsay RE, et al. Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: use of stable isotope methodology. J Clin Pharmacol. 2015;55:1101–8.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Joseph F. Standing
    • 1
  • Brian J. Anderson
    • 2
  • Stefanie Hennig
    • 3
  • Nick H. Holford
    • 4
  • Trevor N. Johnston
    • 5
  • Catherijne A. J. Knibbe
    • 6
  • Dagan O. Lonsdale
    • 7
  • Amin Rostami-Hodjegan
    • 8
  1. 1.UCL Great Ormond Street Institute for Child HealthLondonUK
  2. 2.Department of AnaesthesiaUniversity of AucklandAucklandNew Zealand
  3. 3.School of PharmacyThe University of QueenslandBrisbaneAustralia
  4. 4.Department of Pharmacology and Clinical PharmacologyUniversity of AucklandAucklandNew Zealand
  5. 5.Certara UK Limited, Simcyp DivisionSheffieldUK
  6. 6.Division of Systems Biomedicine and PharmacologyLeiden Academic Centre for Drug Research, University of LeidenLeidenThe Netherlands
  7. 7.Department of Clinical Pharmacology, Institute for Infection and ImmunitySt George’s University of LondonLondonUK
  8. 8.Centre for Applied Pharmacokinetic Research (CAPKR), University of ManchesterManchesterUK

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