Clinical Pharmacokinetics

, Volume 57, Issue 6, pp 663–672 | Cite as

Obesity and Altered Aspirin Pharmacology

  • Nicholas B. Norgard
Review Article


Obesity is an independent risk factor for cardiovascular morbidity and mortality due to atherothrombotic events and represents a group of patients who are in need of optimized antithrombotic therapy. Central to the obesity-related risk of atherothrombosis is a pro-thrombotic state characterized by increased levels of coagulation factors, impaired fibrinolysis, and platelet hyper-reactivity, which results from the interaction among the features clustering in obesity: insulin resistance, inflammation, oxidative stress, and endothelial dysfunction. Aspirin is a cornerstone antiplatelet drug that has substantial interpatient variability in pharmacodynamic response and a number of reports have demonstrated that obesity is a risk factor for a reduced aspirin pharmacodynamic response. The inflammatory state associated with obesity, particularly a metabolic endotoxemia, may set in motion a number of mechanisms that increase platelet reactivity and platelet turnover and decrease aspirin bioavailability, all contributing to a poor aspirin response. A greater understanding of the mechanisms underlying obesity-related high on-aspirin platelet reactivity will help in optimization of antithrombotic therapy in this patient population.


Compliance with Ethical Standards


No external funding was used in the preparation of this review.

Conflict of interest

Nicholas B. Norgard declares that he has no conflicts of interest that might be relevant to the contents of this review.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.University of Missouri-Kansas City School of MedicineKansas CityUSA

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