Clinical Pharmacokinetics

, Volume 55, Issue 5, pp 637–639 | Cite as

Author’s reply to Veloso HH Comment on “The Role of Digitalis Pharmacokinetics in Converting Atrial Fibrillation and Flutter to Sinus Rhythm”

  • Roger W. JelliffeEmail author
Letter to the Editor

I thank Dr. Veloso for a most thoughtful letter [1] supporting my findings that digitalis glycosides are capable not only of converting patients with atrial fibrillation, and even chronic stable atrial flutter for 3 years, to regular sinus rhythm (RSR), but also of maintaining them in RSR for at least 2–4 weeks [2]. Hearing this is a real breath of fresh air after so many years of being isolated by the main community of cardiologists. Thank you also for the other references, which I had not been aware of. It certainly looks like a carefully thought out randomized trial should be conducted to study this issue further.

In my experience, medical schools worldwide have failed to incorporate modern pharmacokinetics into the education of medical students in any clinically meaningful way. As a result, most physicians all over the world have failed to become acquainted with modern pharmacokinetic knowledge. My experience at the yearly meetings of the American Heart Association in Chicago in...


Atrial Fibrillation Digoxin Therapeutic Drug Monitoring Ventricular Rate Peripheral Compartment 
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Compliance with Ethical Standards


No external sources of funding were used in the preparation of this manuscript.

Conflicts of interest

Roger W. Jelliffe has no conflicts of interest that might be relevant to the contents of this manuscript.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Professor of Medicine EmeritusUSC School of MedicineLos AngelesUSA
  2. 2.Founder and Director EmeritusLaboratory of Applied Pharmacokinetics and BioinformaticsLos AngelesUSA
  3. 3.Children’s Hospital of Los AngelesLos AngelesUSA

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