Clinical Pharmacokinetics

, Volume 53, Issue 3, pp 205–212 | Cite as

Role of Microdialysis in Pharmacokinetics and Pharmacodynamics: Current Status and Future Directions

  • Francine Johansson Azeredo
  • Teresa Dalla Costa
  • Hartmut DerendorfEmail author
Review Article


Diagnostic and therapeutic decisions in medical practice are still generally based on blood concentrations of drugs and/or biomolecules despite the knowledge that biochemical events and pharmacological effects usually take place in tissue rather than in the bloodstream. Microdialysis is a semi-invasive technique that is able to measure concentrations of the free, active drug or endogenous compounds in almost all human tissues and organs. It is currently being used to monitor brain metabolic processes and quantify tissue biomarkers, and determine transdermal drug distribution and tissue pharmacokinetics, confirming its importance as a widely used sampling technique in clinical drug monitoring and drug development as well as therapy and disease follow-up, contributing to rationalizing drug dosing regimens and influencing the clinical decision-making process.


Minimum Inhibitory Concentration Deep Brain Stimulation Cerebral Spinal Fluid Microdialysis Probe Doripenem 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This manuscript was not supported by any grant. No founding sources were used in the preparation of this review and the authors have no conflicts of interest regarding the content of this review.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Francine Johansson Azeredo
    • 1
  • Teresa Dalla Costa
    • 1
  • Hartmut Derendorf
    • 2
    Email author
  1. 1.Programa de Pós-Graduação em Ciências FarmacêuticasUFRGSPorto AlegreBrazil
  2. 2.Department of Pharmaceutics, College of PharmacyUniversity of FloridaGainesvilleUSA

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