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The Challenges of Studying Peripheral Vestibular Vertigo

  • James G. NaplesEmail author
Letter to the Editor
  • 28 Downloads

Dear Editor,

I am writing in response to the recent article regarding the efficacy and safety of cinnarizine/dimenhydrinate versus betahistine in patients with peripheral vestibular vertigo by Scholtz et al. [1]. I would like to commend the authors and institutions for organizing and executing such a complicated study. In the otolaryngology literature, blinded, randomized trials are uncommon, as such, this work is an important step in acquiring sound methodological information. Additionally, I think there is reasonable molecular and basic science evidence to suggest there may be an important role for calcium as an ion that is essential in regulatory function of the vestibular system [2, 3]. Calcium-channel blockers (CCBs) were introduced as a possible therapy decades ago [4], and a combination therapy with CCBs is an important concept to build upon since it has not gained wide-spread use—at least in the USA. While the methodology and basic science are valid, there are always...

Notes

Compliance with Ethical Standards

Funding

No funding was received to prepare this letter.

Conflict of interest

The author declares no conflict of interest.

References

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    Scholtz AW, Hahn A, Stefflova B, et al. Efficacy and safety of a fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg vs betahistine dihydrochloride 16 mg in patients with peripheral vestibular vertigo: a prospective, multinational, multicenter, double-blind, randomized. Non-inferiority clinical trial. Clin Drug Investig. 2019;39(11):1045–56.CrossRefGoogle Scholar
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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Otolaryngology-Head and Neck Surgery, Harvard Medical SchoolBeth Israel Deaconess Medical CenterBostonUSA

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