The Challenges of Studying Peripheral Vestibular Vertigo
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I am writing in response to the recent article regarding the efficacy and safety of cinnarizine/dimenhydrinate versus betahistine in patients with peripheral vestibular vertigo by Scholtz et al. . I would like to commend the authors and institutions for organizing and executing such a complicated study. In the otolaryngology literature, blinded, randomized trials are uncommon, as such, this work is an important step in acquiring sound methodological information. Additionally, I think there is reasonable molecular and basic science evidence to suggest there may be an important role for calcium as an ion that is essential in regulatory function of the vestibular system [2, 3]. Calcium-channel blockers (CCBs) were introduced as a possible therapy decades ago , and a combination therapy with CCBs is an important concept to build upon since it has not gained wide-spread use—at least in the USA. While the methodology and basic science are valid, there are always...
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The author declares no conflict of interest.
- 1.Scholtz AW, Hahn A, Stefflova B, et al. Efficacy and safety of a fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg vs betahistine dihydrochloride 16 mg in patients with peripheral vestibular vertigo: a prospective, multinational, multicenter, double-blind, randomized. Non-inferiority clinical trial. Clin Drug Investig. 2019;39(11):1045–56.CrossRefGoogle Scholar
- 6.Scholtz AW, Steindl R, Burchardi N, et al. Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind, non-inferiority study. Clin Drug Investig. 2012;32(6):387–99.CrossRefGoogle Scholar