Clinical Drug Investigation

, Volume 34, Issue 8, pp 587–591

Preliminary, Open-Label, Pilot Study of Add-On Oral Δ9-Tetrahydrocannabinol in Chronic Post-Traumatic Stress Disorder

  • Pablo Roitman
  • Raphael Mechoulam
  • Rena Cooper-Kazaz
  • Arieh Shalev
Short Communication

DOI: 10.1007/s40261-014-0212-3

Cite this article as:
Roitman, P., Mechoulam, R., Cooper-Kazaz, R. et al. Clin Drug Investig (2014) 34: 587. doi:10.1007/s40261-014-0212-3


Background and Objectives

Many patients with post-traumatic stress disorder (PTSD) achieve but partial remission with current treatments. Patients with unremitted PTSD show high rates of substance abuse. Marijuana is often used as compassion add-on therapy for treatment-resistant PTSD. This open-label study evaluates the tolerance and safety of orally absorbable Δ9-tetrahydrocannabinol (THC) for chronic PTSD.


Ten outpatients with chronic PTSD, on stable medication, received 5 mg of Δ9-THC twice a day as add-on treatment.


There were mild adverse effects in three patients, none of which led to treatment discontinuation. The intervention caused a statistically significant improvement in global symptom severity, sleep quality, frequency of nightmares, and PTSD hyperarousal symptoms.


Orally absorbable Δ9-THC was safe and well tolerated by patients with chronic PTSD.

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Pablo Roitman
    • 1
    • 5
  • Raphael Mechoulam
    • 2
  • Rena Cooper-Kazaz
    • 3
  • Arieh Shalev
    • 1
    • 4
  1. 1.Department of PsychiatryHadassah Hebrew University Medical CenterJerusalemIsrael
  2. 2.Institute for Drug ResearchHebrew University School of PharmacyJerusalemIsrael
  3. 3.Psychiatry DepartmentClalit Health ServicesJerusalemIsrael
  4. 4.Department of Psychiatry, Steven and Alexandra Cohen Veterans Center for the Study of Post-Traumatic Stress and Traumatic Brain InjuryNew York University Langone Medical CenterNew YorkUSA
  5. 5.Mate YehudaIsrael

Personalised recommendations