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BioDrugs

, Volume 30, Issue 6, pp 571–584 | Cite as

Immune-Related Adverse Events Associated with Immune Checkpoint Inhibitors

  • Daphne Day
  • Aaron R. HansenEmail author
Review article

Abstract

Immune checkpoint inhibitors (ICIs), including antibodies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein-1 (PD-1), have shown durable treatment responses in multiple tumor types by enhancing antitumor immunity. However, removal of self-tolerance can induce autoimmunity and produce a unique immune-driven toxicity profile, termed immune-related adverse events (irAEs). As ICIs gain approval for a growing number of indications, it is imperative clinicians increase their knowledge of and ability to manage irAEs. This review examines the etiology, presentation, kinetics, and treatment of irAEs and aims to provide practical guidance for clinicians.

Keywords

Melanoma Renal Cell Carcinoma Sunitinib Ipilimumab Pazopanib 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Compliance with Ethical Standards

Conflict of interest

Daphne Day and Aaron R. Hansen have no conflicts of interest.

Funding

Daphne Day is an OICR (Ontario Institute of Cancer Research) Research Fellow and is supported by the Ontario Institute for Cancer Research through funding provided by the Government of Ontario.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Bras Drug Development Program, Division of Medical Oncology and HematologyPrincess Margaret Cancer CentreTorontoCanada
  2. 2.Department of MedicineUniversity of TorontoTorontoCanada
  3. 3.OICR Research FellowOntario Institute for Cancer ResearchTorontoCanada

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