BioDrugs

, Volume 28, Issue 1, pp 7–16

Treg Vaccination in Autoimmune Type 1 Diabetes

  • Isabelle Serr
  • Benno Weigmann
  • Randi Kristina Franke
  • Carolin Daniel
Leading Article

Abstract

Foxp3+ regulatory T (Treg) cells are critical contributors to the establishment and maintenance of immunological self-tolerance. Autoimmune type 1 diabetes (T1D) is characterized by the loss of self-tolerance to the insulin-producing β cells in the pancreas and the destruction of β cells, resulting in the development of chronic hyperglycemia at diagnosis. The application of strong-agonistic T-cell receptor ligands provided under subimmunogenic conditions functions as a critical means for the efficient de novo conversion of naive CD4+ T cells into Foxp3+ Treg cells. The specific induction of Treg cells upon supply of strong-agonistic variants of certain self-antigens could therefore function as a critical instrument in order to achieve safe and specific prevention of autoimmunity such as T1D via the restoration of self-tolerance. Such immunotherapeutic strategies are being developed, and in the case of T1D aim to restrict autoimmunity and β-cell destruction. In this review, we discuss the requirements and opportunities for Treg-based tolerance approaches with the goal of interfering with autoimmune T1D.

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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Isabelle Serr
    • 1
  • Benno Weigmann
    • 2
  • Randi Kristina Franke
    • 1
  • Carolin Daniel
    • 1
  1. 1.Junior Group Immunological Tolerance in Type 1 Diabetes, Institute of Diabetes Research 1Helmholtz Zentrum Muenchen-German Center for Environmental Health (GmbH)MuenchenGermany
  2. 2.Medical Clinic IUniversity Erlangen-NuernbergErlangenGermany

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