, Volume 28, Issue 1, pp 17–26

Second-Generation Tyrosine Kinase Inhibitors in First-Line Treatment of Chronic Myeloid Leukaemia (CML)

  • Elisabetta Abruzzese
  • Massimo Breccia
  • Roberto Latagliata
Review Article


Tyrosine kinase inhibitors (TKIs) have contributed to marked improvements in survival in patients with chronic myeloid leukaemia (CML). This article discusses the place of the second-generation TKIs dasatinib and nilotinib in the first-line treatment of CML and is based on published literature. The new agents are more potent and effective than imatinib. Data from pivotal clinical trials indicate that response to dasatinib and nilotinib is greater and more rapid than that to imatinib, resulting in a higher probability of patients achieving an optimal response to treatment. Differences between the newer agents with respect to patient groups for whom caution is advised, drug interaction potential, haematological toxicity, pulmonary toxicity, changes in the immune system and effects on laboratory parameters are discussed. With similar levels of efficacy, the choice of second-generation agents should be guided by the characteristics of the individual patient and the most suitable dosing regimen.

Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Elisabetta Abruzzese
    • 1
  • Massimo Breccia
    • 2
  • Roberto Latagliata
    • 3
  1. 1.HematologyS. Eugenio Hospital, Tor Vergata UniversityRomeItaly
  2. 2.Department of Cellular Biotechnology and HematologySapienza UniversityRomeItaly
  3. 3.Department of Cellular Biotechnologies and HematologySapienza University of RomeRomeItaly

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