BioDrugs

, Volume 27, Issue 3, pp 175–180 | Cite as

Stem Cell Therapy in Osteoarthritis: A Step Too Far?

Current Opinion

Abstract

Osteoarthritis (OA) is the most common joint disease and, until now, no effective medical treatment has been developed, apart from total joint replacement in end-stage disease. Since mesenchymal stem cells (MSC) can on one hand be the source of newly formed cartilage, and on the other hand inhibit inflammation with their immunomodulatory capacities, these cells are, on a theoretical basis, ideal for the treatment of OA. As a result, MSC-based treatments for OA patients are currently offered worldwide. However, the effectiveness of this treatment and the potential associated risks are not well known. To develop MSC-based treatment of OA into a generally accepted, clinically effective and safe cure, extensive studies have to be performed in controlled experimental and clinical settings. Stem cell therapy is a remedy with the potential for a great future; however, this outlook could be jeopardized if this treatment is introduced too early into clinical practice.

Notes

Acknowledgments

No sources of funding were used to prepare this manuscript. The author has no conflicts of interest that are directly relevant to the content of this article.

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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  1. 1.Department of RheumatologyRadboud University, Medical CentreNijmegenThe Netherlands

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