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American Journal of Clinical Dermatology

, Volume 20, Issue 1, pp 115–122 | Cite as

Antibody-Based Therapies for Cutaneous T-Cell Lymphoma

  • Macartney WelbornEmail author
  • Madeleine Duvic
Review Article

Abstract

Cutaneous T-cell lymphomas (CTCLs) are a group of non-Hodgkin’s lymphomas that present in the skin. In early-stage disease, the course is generally chronic and indolent; however, in advanced stages of disease, therapies rarely provide long-lasting responses, and the only potential curative therapy is allogeneic hematopoietic stem-cell transplantation. This has led to the search for novel targeted therapies to better treat more advanced stages of CTCLs that cannot be controlled by typical treatment regimens. One area of advancement has been the development of antibodies specifically targeted to cell types that are known to be involved in CTCL. At present, brentuximab vedotin, an antibody–drug conjugate composed of an anti-cluster of differentiation (CD)-30 antibody covalently linked to monomethyl auristatin E, is approved for the treatment of CD30+ lymphoproliferative disorders [lymphomatoid papulosis (LyP) and primary cutaneous-anaplastic large-cell lymphoma (pc-ALCL)] as well as transformed CD30+ mycosis fungoides (MF). Additionally, mogamulizumab, an anti-chemokine receptor 4 (CCR4) monoclonal antibody, is approved for patients with MF or Sézary syndrome (SS) for whom one prior systemic therapy has failed. Trials are underway looking into the use of immune checkpoint inhibitors in the treatment of CTCLs. As we continue to research CTCL, and as antibody-based therapies continue to advance, more antibody-specific targeted therapy could provide alternative treatment regimens for patients with advanced CTCL.

Notes

Compliance with Ethical Standards

Funding

No sources of funding were used to conduct this study or prepare this manuscript.

Conflict of Interest

Madeleine Duvic is science and advisory committee member for Millennium Pharmaceuticals, consulting and science advisor for Kyowa Pharmaceuticals, and on the advisory board for Seattle Genetics. Macartney Welborn has no conflicts of interest that are directly relevant to the content of this article.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.University of Texas McGovern Medical SchoolHoustonUSA
  2. 2.University of Texas MD Anderson Cancer CenterHoustonUSA

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