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Dermatologic Conditions of the Early Post-Transplant Period in Hematopoietic Stem Cell Transplant Recipients

  • Cynthia X. Wang
  • Milan J. Anadkat
  • Amy C. Musiek
Review Article

Abstract

Hematopoietic stem cell transplants (HSCTs) are used to treat a variety of conditions, including hematologic malignancies, bone marrow failure syndromes, and immunodeficiencies. Over 60,000 HSCTs are performed annually worldwide, and the numbers continue to increase. Indeed, as new conditioning regimens develop, more and more individuals, including those of older age, will be eligible for transplants. Nevertheless, although HSCTs are clearly a life-saving and necessary treatment for thousands of patients per year, there is still substantial morbidity and mortality associated with the procedure. Of note, skin eruptions in the post-HSCT period are frequent and often significantly reduce quality of life in recipients. Moreover, these cutaneous findings sometimes herald an underlying systemic condition, presenting possible opportunities for timelier intervention. Dermatologists therefore play a vital role in distinguishing life-threatening conditions from benign issues and prompting recognition of critical complications earlier in their course. This article aims to review the major dermatologic conditions occurring in the early post-HSCT period.

Notes

Acknowledgements

The authors thank Dr. Leo Shmuylovich, MD/PhD, and Dr. Douglas Laurain, MD, for assisting with select photographs in this review.

Compliance with Ethical Standards

Funding

No sources of funding were used to conduct this study or prepare this manuscript.

Conflict of Interest

CXW, MJA, and ACM have no conflicts of interest that are directly relevant to the content of this review.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Cynthia X. Wang
    • 1
  • Milan J. Anadkat
    • 1
    • 2
  • Amy C. Musiek
    • 1
    • 2
  1. 1.Washington University School of MedicineSt. LouisUSA
  2. 2.Division of DermatologyWashington University School of MedicineSt. LouisUSA

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