American Journal of Clinical Dermatology

, Volume 18, Issue 2, pp 237–251 | Cite as

Honey and Wound Healing: An Update

  • Sami K. Saikaly
  • Amor KhachemouneEmail author
Review Article


For centuries, honey has been utilized for wound healing purposes. In recent times, this specific topic has become a field of interest, possibly due to the advent of antibiotic resistance in microbial pathogens. With constant technological advancement, the information regarding honey’s mechanisms of action on wound healing has accumulated at a rapid pace. Similarly, clinical studies comparing honey with traditional wound care therapies are steadily emerging. As a follow-up to a previous review published in the journal in 2011, the current review article outlines publications regarding honey and wound healing that have been published between June 2010 and August 2016. Here we describe the most recent evidence regarding multiple types of honey and their mechanisms of action as antimicrobial agents, immunologic modulators, and physiologic mediators. In addition, outcomes of clinical studies involving a multitude of cutaneous wounds are also examined.


Compliance with Ethical Standards


No sources of funding were used to prepare this review.

Conflicts of interest  

The authors have no conflicts of interest that are directly relevant to the content of this review.

Supplementary material

40257_2016_247_MOESM1_ESM.pdf (277 kb)
Supplementary material 1 (PDF 277 kb)


  1. 1.
    Sipos P, Gyory H, Hagymasi K, et al. Special wound healing methods used in ancient egypt and the mythological background. World J Surg. 2004;28(2):211–6.CrossRefPubMedGoogle Scholar
  2. 2.
    Majno G. The healing hand: man and wound in the ancient world. Cambridge: Harvard University Press; 1991.Google Scholar
  3. 3.
    Shizhen L. Bencao Gangmu: compendium of materia medica. Beijing: Foreign Languages Press; 2003.Google Scholar
  4. 4.
    Sahih Bukhari. Volume 7; Book 71: medicine. Hadith #588.Google Scholar
  5. 5.
    Carter DA, Blair SE, Cokcetin NN, et al. Therapeutic manuka honey: no longer so alternative. Front Microbiol. 2016;7:569.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Yaghoobi R, Kazerouni A, Kazerouni O. Evidence for clinical use of honey in wound healing as an anti-bacterial, anti-inflammatory anti-oxidant and anti-viral agent: a review. Jundishapur J Nat Pharm Prod. 2013;8(3):100–4.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Pecanac M, Janjic Z, Komarcevic A, et al. Burns treatment in ancient times. Med Pregl. 2013;66(5–6):263–7.PubMedGoogle Scholar
  8. 8.
    Rogalska T. Healing the bee’s knees-on honey and wound healing. JAMA Dermatol. 2016;152(3):275.CrossRefPubMedGoogle Scholar
  9. 9.
    Oryan A, Alemzadeh E, Moshiri A. Biological properties and therapeutic activities of honey in wound healing: a narrative review and meta-analysis. J Tissue Viability. 2016;25(2):98–118.CrossRefPubMedGoogle Scholar
  10. 10.
    Subrahmanyam M. Honey dressing for burns: an appraisal. Ann Burns Fire Disasters. 1996;9(1):33–5.Google Scholar
  11. 11.
    Dustmann JH. Antibacterial effect of honey. Apiacta. 1979;14(1):7–11.Google Scholar
  12. 12.
    Lee DS, Sinno S, Khachemoune A. Honey and wound healing: an overview. Am J Clin Dermatol. 2011;12(3):181–90.CrossRefPubMedGoogle Scholar
  13. 13.
    Derma Sciences Inc. Accessed 14 Aug 2016.
  14. 14.
    Hussein SZ, Yusoff KM, Makpol S, et al. Does gamma irradiation affect physicochemical properties of honey? Clin Ter. 2014;165(2):e125–33.PubMedGoogle Scholar
  15. 15.
    Israili ZH. Antimicrobial properties of honey. Am J Ther. 2014;21(4):304–23.CrossRefPubMedGoogle Scholar
  16. 16.
    Lu J, Carter DA, Turnbull L, et al. The effect of New Zealand kanuka, manuka and clover honeys on bacterial growth dynamics and cellular morphology varies according to the species. PloS One. 2013;8(2):e55898.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Henriques AF, Jenkins RE, Burton NF, et al. The effect of manuka honey on the structure of Pseudomonas aeruginosa. Eur J Clin Microbiol Infect Dis. 2011;30(2):167–71.CrossRefPubMedGoogle Scholar
  18. 18.
    Cooke J, Dryden M, Patton T, et al. The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide. BMC Res Notes. 2014;8:20.CrossRefGoogle Scholar
  19. 19.
    Majtan J. Honey: an immunomodulator in wound healing. Wound Repair Regen. 2014;22(2):187–92.CrossRefPubMedGoogle Scholar
  20. 20.
    Majtan J, Klaudiny J, Bohova J, et al. Methylglyoxal-induced modifications of significant honeybee proteinous components in manuka honey: possible therapeutic implications. Fitoterapia. 2012;83(4):671–7.CrossRefPubMedGoogle Scholar
  21. 21.
    Kato Y, Umeda N, Maeda A, et al. Identification of a novel glycoside, leptosin, as a chemical marker of manuka honey. J Agric Food Chem. 2012;60(13):3418–23.CrossRefPubMedGoogle Scholar
  22. 22.
    Roberts AE, Maddocks SE, Cooper RA. Manuka honey reduces the motility of Pseudomonas aeruginosa by suppression of flagella-associated genes. J Antimicrob Chemother. 2015;70(3):716–25.CrossRefPubMedGoogle Scholar
  23. 23.
    Kronda JM, Cooper RA, Maddocks SE. Manuka honey inhibits siderophore production in Pseudomonas aeruginosa. J Appl Microbiol. 2013;115(1):86–90.CrossRefPubMedGoogle Scholar
  24. 24.
    Jenkins RE, Cooper R. Synergy between oxacillin and manuka honey sensitizes methicillin-resistant Staphylococcus aureus to oxacillin. J Antimicrob Chemother. 2012;67(6):1405–7.CrossRefPubMedGoogle Scholar
  25. 25.
    Gannabathula S, Skinner MA, Rosendale D, et al. Arabinogalactan proteins contribute to the immunostimulatory properties of New Zealand honeys. Immunopharmacol Immunotoxicol. 2012;34(4):598–607.CrossRefPubMedGoogle Scholar
  26. 26.
    Hussein SZ, Mohd Yusoff K, Makpol S, et al. Gelam honey inhibits the production of proinflammatory, mediators NO, PGE(2), TNF-alpha, and IL-6 in carrageenan-induced acute paw edema in rats. Evid Based Complement Alternat Med. 2012;2012:109636.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Almasaudi SB, El-Shitany NA, Abbas AT, et al. Antioxidant, anti-inflammatory, and antiulcer potential of manuka honey against gastric ulcer in rats. Oxid Med Cell Longev. 2016;2016:3643824.CrossRefPubMedGoogle Scholar
  28. 28.
    Leong AG, Herst PM, Harper JL. Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities. Innate Immun. 2012;18(3):459–66.CrossRefPubMedGoogle Scholar
  29. 29.
    Fukuda M, Kobayashi K, Hirono Y, et al. Jungle honey enhances immune function and antitumor activity. Evid Based Complement Alternat Med. 2011;2011:908743.CrossRefPubMedGoogle Scholar
  30. 30.
    Velnar T, Bailey T, Smrkolj V. The wound healing process: an overview of the cellular and molecular mechanisms. J Int Med Res. 2009;37(5):1528–42.CrossRefPubMedGoogle Scholar
  31. 31.
    Molan PC. The evidence and the rationale for the use of honey as wound dressing. Wound Pract Res. 2011;19(4):204–20.Google Scholar
  32. 32.
    Al-Waili N, Salom K, Al-Ghamdi AA. Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. Sci World J. 2011;11:766–87.CrossRefGoogle Scholar
  33. 33.
    Al-Waili NS. Identification of nitric oxide metabolites in various honeys: effects of intravenous honey on plasma and urinary nitric oxide metabolites concentrations. J Med Food. 2003;6(4):359–64.CrossRefPubMedGoogle Scholar
  34. 34.
    Al-Waili NS, Boni NS. Honey increased saliva, plasma, and urine content of total nitrite concentrations in normal individuals. J Med Food. 2004;7(3):377–80.CrossRefPubMedGoogle Scholar
  35. 35.
    Al-Waili NS, Salom K, Butler G, et al. Honey and microbial infections: a review supporting the use of honey for microbial control. J Med Food. 2011;14(10):1079–96.CrossRefPubMedGoogle Scholar
  36. 36.
    Majtan J, Bohova J, Garcia-Villalba R, et al. Fir honeydew honey flavonoids inhibit TNF-alpha-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing. Arch Dermatol Res. 2013;305(7):619–27.CrossRefPubMedGoogle Scholar
  37. 37.
    Bromfield R. Honey for decubitus ulcers. JAMA. 1973;224(6):905.CrossRefPubMedGoogle Scholar
  38. 38.
    Armon PJ. The use of honey in the treatment of infected wounds. Trop Doct. 1980;10(2):91.CrossRefPubMedGoogle Scholar
  39. 39.
    Mossel DA. Honey for necrotic breast ulcers. Lancet. 1980;2(8203):1091.CrossRefPubMedGoogle Scholar
  40. 40.
    Keast-Butler J. Honey for necrotic malignant breast ulcers. Lancet. 1980;2(8198):809.CrossRefPubMedGoogle Scholar
  41. 41.
    Bose B. Honey or sugar in treatment of infected wounds? Lancet. 1982;1(8278):963.CrossRefPubMedGoogle Scholar
  42. 42.
    Efem SE. Clinical observations on the wound healing properties of honey. Br J Surg. 1988;75(7):679–81.CrossRefPubMedGoogle Scholar
  43. 43.
    Boekema BK, Pool L, Ulrich MM. The effect of a honey based gel and silver sulphadiazine on bacterial infections of in vitro burn wounds. Burns. 2013;39(4):754–9.CrossRefPubMedGoogle Scholar
  44. 44.
    Maghsoudi H, Salehi F, Khosrowshahi MK, et al. Comparison between topical honey and mafenide acetate in treatment of burn wounds. Ann Burns Fire Disasters. 2011;24(3):132–7.PubMedPubMedCentralGoogle Scholar
  45. 45.
    Gupta SS, Singh O, Bhagel PS, et al. Honey dressing versus silver sulfadiazene dressing for wound healing in burn patients: a retrospective study. J Cutan Aesthet Surg. 2011;4(3):183–7.CrossRefPubMedPubMedCentralGoogle Scholar
  46. 46.
    Zbuchea A. Up-to-date use of honey for burns treatment. Ann Burns Fire Disasters. 2014;27(1):22–30.PubMedPubMedCentralGoogle Scholar
  47. 47.
    Brolmann FE, Ubbink DT, Nelson EA, et al. Evidence-based decisions for local and systemic wound care. Br J Surg. 2012;99(9):1172–83.CrossRefPubMedGoogle Scholar
  48. 48.
    Subrahmanyam M. Dressing accelerates split-thickness skin graft donor site healing. Indian J Surg. 2015;77(Suppl 2):261–3.Google Scholar
  49. 49.
    Parmar JD, Hunjan PS, Brown AN, et al. Honey dressing use for the management of split thickness skin graft donor sites: a technical note. Br J Oral Maxillofac Surg. 2013;51(3):e40–1.CrossRefPubMedGoogle Scholar
  50. 50.
    Anyanechi CE, Saheeb BD. Honey and wound dehiscence: a study of surgical wounds in the mandibular bed. Niger J Clin Pract. 2015;18(2):251–5.CrossRefPubMedGoogle Scholar
  51. 51.
    Nikpour M, Shirvani MA, Azadbakht M, et al. The effect of honey gel on abdominal wound healing in cesarean section: a triple blind randomized clinical trial. Oman Med J. 2014;29(4):255–9.CrossRefPubMedPubMedCentralGoogle Scholar
  52. 52.
    Dryden M, Lockyer G, Saeed K, et al. Engineered honey: In vitro antimicrobial activity of a novel topical wound care treatment. J Glob Antimicrob Resist. 2014;2(3):168–72.CrossRefPubMedGoogle Scholar
  53. 53.
    Dryden M, Goddard C, Madadi A, et al. Using antimicrobial Surgihoney to prevent caesarean wound infection. Br J Midwifery. 2014;22(1):23–7.CrossRefGoogle Scholar
  54. 54.
    Heidari T, Roozbahani N, Amiri Farahani L, et al. Does Iranian Astragalus gossypinus honey assist in healing caesarean wounds and scars? Eur J Integr Med. 2013;5(3):226–33.CrossRefGoogle Scholar
  55. 55.
    Johnson DW, Badve SV, Pascoe EM, et al. Antibacterial honey for the prevention of peritoneal-dialysis-related infections (HONEYPOT): a randomised trial. Lancet Infect Dis. 2014;14(1):23–30.CrossRefPubMedGoogle Scholar
  56. 56.
    Jarjis DR, Crewe TB, Matzen HS. Post-bariatric abdominoplasty resulting in wound infection and dehiscence-Conservative treatment with medical grade honey: a case report and review of literature. Int J Surg Case Rep. 2016;20:1–3.CrossRefGoogle Scholar
  57. 57.
    Majtanova N, Vodrazkova E, Kurilova V, et al. Complementary treatment of contact lens-induced corneal ulcer using honey: a case report. Cont Lens Anterior Eye. 2015;38(1):61–3.CrossRefPubMedGoogle Scholar
  58. 58.
    Okeniyi JA, Olubanjo OO, Ogunlesi TA, et al. Comparison of healing of incised abscess wounds with honey and EUSOL dressing. J Altern Complement Med. 2005;11(3):511–3.CrossRefPubMedGoogle Scholar
  59. 59.
    Biglari B, vd Linden PH, Simon A, et al. Use of Medihoney as a non-surgical therapy for chronic pressure ulcers in patients with spinal cord injury. Spinal Cord. 2012;50(2):165–9.CrossRefPubMedGoogle Scholar
  60. 60.
    Khadanga SDD, Karuna T, Khetri R, et al. Effects of topical honey dressing in decubitus ulcer. Asian J Med Sci. 2015;6(4):99–101.CrossRefGoogle Scholar
  61. 61.
    Saha A, Chattopadhyay S, Azam M, et al. The role of honey in healing of bedsores in cancer patients. South Asian J Cancer. 2012;1(2):66–71.CrossRefPubMedPubMedCentralGoogle Scholar
  62. 62.
    Imran M, Hussain MB, Baig M. A randomized, controlled clinical trial of honey-impregnated dressing for treating diabetic foot ulcer. J Coll Phys Surg Pak. 2015;25(10):721–5.Google Scholar
  63. 63.
    Kamaratos AV, Tzirogiannis KN, Iraklianou SA, et al. Manuka honey-impregnated dressings in the treatment of neuropathic diabetic foot ulcers. Int Wound J. 2014;11(3):259–63.CrossRefPubMedGoogle Scholar
  64. 64.
    Majtan J. Methylglyoxal—a potential risk factor of manuka honey in healing of diabetic ulcers. Evid Based Complement Alternat Med. 2011;2011:295494.CrossRefPubMedGoogle Scholar
  65. 65.
    Prasad A, Bekker P, Tsimikas S. Advanced glycation end products and diabetic cardiovascular disease. Cardiol Rev. 2012;20(4):177–83.CrossRefPubMedGoogle Scholar
  66. 66.
    Gulati S, Qureshi A, Srivastava A, et al. A prospective randomized study to compare the effectiveness of honey dressing vs. povidone iodine dressing in chronic wound healing. Indian J Surg. 2014;76(3):193–8.CrossRefPubMedGoogle Scholar
  67. 67.
    Holland LC, Norris JM. Medical grade honey in the management of chronic venous leg ulcers. Int J Surg. 2015;20:17–20.CrossRefPubMedGoogle Scholar
  68. 68.
    Ruttermann M, Maier-Hasselmann A, Nink-Grebe B, et al. Local treatment of chronic wounds: in patients with peripheral vascular disease, chronic venous insufficiency, and diabetes. Dtsch Arztebl Int. 2013;110(3):25–31.PubMedPubMedCentralGoogle Scholar
  69. 69.
    Zerm R. Topical honey for diabetic foot ulcers. Dtsch Arztebl Int. 2013;110(21):373.PubMedPubMedCentralGoogle Scholar
  70. 70.
    Thomas M, Hamdan M, Hailes S, et al. Manuka honey as an effective treatment for chronic pilonidal sinus wounds. J Wound Care. 2011;20(11):528, 530–523.Google Scholar
  71. 71.
    Haidari M, Nazer MR, Ahmadinejad M, et al. Honey in the treatment of Fournier’s gangrene as an adjuvant: a cross sectional study. J Pak Med Assoc. 2014;64(5):571–3.PubMedGoogle Scholar
  72. 72.
    Biglari B, Moghaddam A, Santos K, et al. Multicentre prospective observational study on professional wound care using honey (Medihoney). Int Wound J. 2013;10(3):252–9.CrossRefPubMedGoogle Scholar
  73. 73.
    Dryden M, Dickinson A, Brooks J, et al. A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds. J Wound Care. 2016;25(3):140, 142–146.Google Scholar
  74. 74.
    Maiti PK, Ray A, Mitra TN, et al. The effect of honey on mucositis induced by chemoradiation in head and neck cancer. J Indian Med Assoc. 2012;110(7):453–6.PubMedGoogle Scholar
  75. 75.
    Hawley P, Hovan A, McGahan CE, et al. A randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis. Support Care Cancer. 2014;22(3):751–61.CrossRefPubMedGoogle Scholar
  76. 76.
    Bardy J, Molassiotis A, Ryder WD, et al. A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis. Br J Oral Maxillofac Surg. 2012;50(3):221–6.CrossRefPubMedGoogle Scholar
  77. 77.
    Lund-Nielsen B, Adamsen L, Kolmos HJ, et al. The effect of honey-coated bandages compared with silver-coated bandages on treatment of malignant wounds-a randomized study. Wound Repair Regen. 2011;19(6):664–70.CrossRefPubMedGoogle Scholar
  78. 78.
    Drain J, Fleming MO. Palliative management of malodorous squamous cell carcinoma of the oral cavity with Manuka honey. J Wound Ostomy Continence Nurs. 2015;42(2):190–2.CrossRefPubMedGoogle Scholar
  79. 79.
    Lund-Nielsen B, Adamsen L, Gottrup F, et al. Qualitative bacteriology in malignant wounds—a prospective, randomized, clinical study to compare the effect of honey and silver dressings. Ostomy Wound Manag. 2011;57(7):28–36.Google Scholar
  80. 80.
    Jull AB, Cullum N, Dumville JC, et al. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;(3):Cd005083. doi: 10.1002/14651858.CD005083.pub4.
  81. 81.
    Lindberg T, Andersson O, Palm M, et al. A systematic review and meta-analysis of dressings used for wound healing: the efficiency of honey compared to silver on burns. Contemp Nurse. 2015;51(2–3):121–34.CrossRefPubMedGoogle Scholar
  82. 82.
    Vandamme L, Heyneman A, Hoeksema H, et al. Honey in modern wound care: a systematic review. Burns. 2013;39(8):1514–25.CrossRefPubMedGoogle Scholar
  83. 83.
    Norman G, Dumville JC, Mohapatra DP, et al. Antibiotics and antiseptics for surgical wounds healing by secondary intention. Cochrane Database Syst Rev. 2016;3:Cd011712.PubMedGoogle Scholar
  84. 84.
    Rankin RS. New Mexico honey wound treatment research study [ Identifier NCT01748318]. US National Institutes of Health, Accessed 7 Aug 2016.
  85. 85.
    New York City Health and Hospitals Corporation. Leptospermum scoparium honey and wound care for pressure ulcers [ Identifier: NCT02689310]. US National Institutes of Health, Accessed 7 Aug 2016.
  86. 86.
    Centre Hospitalier Universitaire de Nīmes. Efficacy and tolerance of honey-impregnated dressings in the local management of pressure ulcers (MeliCare) [ Identifier: NCT02373956]. US National Institutes of Health, Accessed 7 Aug 2016.
  87. 87.
    Medline Industries. Wound management for sacral pressure ulcers with necrotic tissue [ Identifier: NCT02224638]. US National Institutes of Health, Accessed 7 Aug 2016.
  88. 88.
    Icahn School of Medicine at Mount Sinai. Manuka honey for wound care [ Identifier: NCT02259491]. US National Institutes of Health, Accessed 7 Aug 2016.
  89. 89.
    Allegheny Singer Research Institute. Medihoney and santyl for burn injuries (MSBI) [ Identifier: NCT02250183]. US National Institutes of Health, Accessed 7 Aug 2016.
  90. 90.
    Centre Hospitalier Departemental Vendee. Interest in the use of dressings with honey for wound healing after excision of pilonidal cyst (Pilomiel) [ Identifier: NCT02485860]. US National Institutes of Health, Accessed 7 Aug 2016.
  91. 91.
    HaEmek Medical Center-Israel. The effect of anti-bacterial honey dressing on the healing of split thickness skin graft donor site [ Identifier: NCT02400372]. US National Institutes of Health, Accessed 7 Aug 2016.
  92. 92.
    University of Missouri-Columbia. The Efficacy of “MediHoney” to facilitate catheter exit-site surgical wound healing [ Identifier: NCT01230489]. US National Institutes of Health, Accessed 7 Aug 2016.
  93. 93.
    Tirado DJ, Hudson NR, Maldonado CJ. Efficacy of medical grade honey against multidrug-resistant organisms of operational significance: part I. J Trauma Acute Care Surg. 2014;77(3 Suppl 2):S204–7.CrossRefPubMedGoogle Scholar
  94. 94.
    Jenkins R, Cooper R. Improving antibiotic activity against wound pathogens with manuka honey in vitro. PloS One. 2012;7(9):e45600.CrossRefPubMedPubMedCentralGoogle Scholar
  95. 95.
    Muller P, Alber DG, Turnbull L, et al. Synergism between Medihoney and rifampicin against methicillin-resistant Staphylococcus aureus (MRSA). PloS One. 2013;8(2):e57679.CrossRefPubMedPubMedCentralGoogle Scholar
  96. 96.
    Liu M, Lu J, Muller P, et al. Antibiotic-specific differences in the response of Staphylococcus aureus to treatment with antimicrobials combined with manuka honey. Front Microbiol. 2014;5:779.CrossRefPubMedGoogle Scholar
  97. 97.
    Shahzad A, Cohrs RJ. In vitro antiviral activity of honey against varicella zoster virus (VZV): a translational medicine study for potential remedy for shingles. Transl Biomed. 2012;3(2):2–7.Google Scholar
  98. 98.
    Gibson DJ, Yang Q, Kerekes DT, et al. Medical honey and silver dressings do not interfere with each other’s key functional attributes. Wounds. 2014;26(11):309–16.PubMedGoogle Scholar
  99. 99.
    Boyar V, Handa D, Clemens K, et al. Clinical experience with Leptospermum honey use for treatment of hard to heal neonatal wounds: case series. J Perinatol. 2014;34(2):161–3.CrossRefPubMedGoogle Scholar
  100. 100.
    Amaya R. Safety and efficacy of active Leptospermum honey in neonatal and paediatric wound debridement. J Wound Care. 2015;24(3):95, 97–103.Google Scholar
  101. 101.
    Mohr LD, Reyna R, Amaya R. Neonatal case studies using active Leptospermum honey. J Wound Ostomy Continence Nurs. 2014;41(3):213–8.CrossRefPubMedGoogle Scholar
  102. 102.
    Dryden M, Milward G, Saeed K. Infection prevention in wounds with Surgihoney. J Hosp Infect. 2014;88(2):121–2.CrossRefPubMedGoogle Scholar
  103. 103.
    Gray C, Ishii F. Using active Leptospermum honey in the debridement process: 6 challenging cases from the inner city. Ostomy Wound Manag. 2015;61(4):63–6.Google Scholar
  104. 104.
    Stewart JA, McGrane OL, Wedmore IS. Wound care in the wilderness: is there evidence for honey? Wilderness Environ Med. 2014;25(1):103–10.CrossRefPubMedGoogle Scholar
  105. 105.
    Ahmed S, Othman NH. Review of the medicinal effects of tualang honey and a comparison with manuka honey. Malays J Med Sci. 2013;20(3):6–13.PubMedPubMedCentralGoogle Scholar
  106. 106.
    Boateng J, Diunase KN. Comparing the antibacterial and functional properties of cameroonian and manuka honeys for potential wound healing-have we come full cycle in dealing with antibiotic resistance? Molecules. 2015;20(9):16068–84.CrossRefPubMedGoogle Scholar
  107. 107.
    Gomes S, Dias LG, Moreira LL, Rodrigues P, Estevinho L. Physicochemical, microbiological and antimicrobial properties of commercial honeys from Portugal. Food Chem Toxicol. 2010;48(2):544–8.CrossRefPubMedGoogle Scholar
  108. 108.
    McLoone P, Warnock M, Fyfe L. Honey: a realistic antimicrobial for disorders of the skin. J Microbiol Immunol Infect. 2016;49(2):161–7.CrossRefPubMedGoogle Scholar
  109. 109.
    Burlando B, Cornara L. Honey in dermatology and skin care: a review. J Cosmet Dermatol. 2013;12(4):306–13.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.University of Central Florida College of MedicineSaint AugustineUSA
  2. 2.SUNY DownstateBrooklynUSA

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