American Journal of Clinical Dermatology

, Volume 17, Issue 4, pp 359–367 | Cite as

Autologous Platelet-Rich Plasma for the Treatment of Pattern Hair Loss

  • Babu Singh
  • Lynne J. Goldberg
Review Article


Platelet-rich plasma (PRP) is a solution derived from whole blood that is enriched in the platelet fraction. Platelets serve as a reservoir of growth factors and cytokines. When platelets are activated in vivo, signaling molecules are released into the immediate microenvironment and activate receptors for various pathways. Historically, PRP has been applied to wound beds to promote healing of complex wounds. Over the last decade, it has served as a valuable therapeutic tool in various specialties such as maxillofacial surgery, plastic surgery, orthopedics and sports medicine. Only recently has PRP been utilized for dermatologic purposes, more specifically, for the treatment of male and female pattern hair loss. In this review, we discuss molecular and cellular pathways upregulated by PRP important in hair folliculogenesis, and examine clinical evidence from all previously published studies involving the use of PRP for pattern hair loss.


Hair Follicle Finasteride Hair Loss Pyoderma Gangrenosum Dermal Papilla 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to thank Nicole Rogers, MD, FAAD, FISHRS for providing the sample protocol and the clinical photographs.

Compliance with Ethical Standards


No funding was received for the preparation of this review.

Conflict of interest

Babu Singh and Lynne J. Goldberg have no conflicts of interest to declare.


  1. 1.
    Carter MJ, Fylling CP, Parnell LK. Use of Platelet rich plasma gel on wound healing: a systematic review and meta-analysis. Eplasty. 2011;11:e38.PubMedPubMedCentralGoogle Scholar
  2. 2.
    Sommeling CE, Heyneman A, Hoeksema H, et al. The use of platelet-rick plasma in plastic surgery: a systematic review. J Plast Reconstr Aesthet Surg. 2013;66:301–12.CrossRefPubMedGoogle Scholar
  3. 3.
    Curi MM, Cossolin GS, Koga DH, et al. Treatment of avascular osteonecrosis of the jaw in cancer patients with a history of bisphosphonate therapy by combining bone resection and autologous platelet-rich plasma: report of 3 cases. J Oral Maxillofac Sug. 2007;65:348–55.Google Scholar
  4. 4.
    Ronci C, Ferraro AS, Lanti A, et al. Platelet-rich plasma as treatment for persistent ocular epithelial defects. Transfus Apheres Sci. 2015;52(3):300–4.CrossRefGoogle Scholar
  5. 5.
    Uebel CO, da Silva JB, Cantarelli D, et al. The role of platelet plasma growth factors in male pattern baldness surgery. Plast Reconstr Surg. 2006;118(6):1458–66.CrossRefPubMedGoogle Scholar
  6. 6.
    Cayirh M, Cahskan E, Acikgoz G, et al. Regression of melisma with platelet-rich plasma treatment. Ann Dermatol. 2014;26(3):401–2.CrossRefGoogle Scholar
  7. 7.
    Conde-Montero E, Horcajada-Reales C, Clavo P, et al. Neuropathic ulcers in leprosy treated with intralesional platelet-rich plasma. Int Wound J. 2014. doi: 10.1111/iwj.12359.PubMedGoogle Scholar
  8. 8.
    Motolese A, Vignati F, Antelmi A, et al. Effectiveness of platelet-rich plasma in healing necrobiosis lipoidica diabeticorum ulcers. Clin Exp Dermatol. 2015;40(1):39–41.CrossRefPubMedGoogle Scholar
  9. 9.
    Casabona F, Priano V, Vallerino V, et al. New surgical approach to lichen sclerosis of the vulva: the role of adipose-derived mesenchymal cells and platelet-rich plasma in tissue regeneration. Plast Reconstr Surg. 2010;126(4):210e–211e.CrossRefPubMedGoogle Scholar
  10. 10.
    Budamakuntla L, Suryanarayan S, Sarvajnamurthy SS, et al. Autologous platelet rich plasma in pyoderma gangrenosum—two case reports. Indian J Dermatol. 2015;60(2):204–5.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Dhurat R, Sukesh MS. Principles and methods of preparation of platelet-rich plasma: a review and author’s perspective. J Cutan Aesthet Surg. 2014;7:189–99.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Raja SV, Naidu ME. Platelet-rich fibrin: evolution of a second-generation platelet concentrate. Indian J Dent Res. 2008;19:42–6.CrossRefGoogle Scholar
  13. 13.
    Senzel L, Gnatenko DV, Bahou WF. The platelet proteome. Curr Opin Hematol. 2009;5:329–33.CrossRefGoogle Scholar
  14. 14.
    Li ZJ, Hi Choi, Choi DK, et al. Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Dermatol Surg. 2012;38(7):1040–6.CrossRefPubMedGoogle Scholar
  15. 15.
    Singhal P, Agarwal S, Dhot PS, et al. Efficacy of platelet-rich plasma in treatment of androgenetic alopecia. Asian J Transfus Sci. 2015;9(2):159–62.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Gentile P, Garcovich S, Bielli A, et al. The effect of platelet-rich plasma in hair regrowth: a randomized placebo-controlled trial. Stem Cells Transl Med. 2015. doi: 10.5966/sctm.2015-0107.PubMedGoogle Scholar
  17. 17.
    Marwah M, Dogse K, Patil S, et al. Is there sufficient research data to use platelet-rich plasma in dermatology? Int J Trichol. 2014;6:35–6.CrossRefGoogle Scholar
  18. 18.
    Khatu SS, More YE, Gokhale NR, et al. Platelet-rich plasma in androgenic alopecia: myth or an effective tool. J Cutan Aesthet Surg. 2014;7:107–10.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Cervelli V, Garcovich S, Bielli A, et al. The effect of autologous activated platelet right plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int. 2014. doi: 10.1155/2014/760709.Google Scholar
  20. 20.
    Gkini MA, Kouskoukis AE, Tripsianis G, et al. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg. 2014;7(4):213–9.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Kang JS, Zheng Z, Choi MJ, et al. The effect of CD34+ cell-combining autologous platelet rich plasma injection on pattern hair loss: a preliminary study. JEADV. 2014;28:72–9.PubMedGoogle Scholar
  22. 22.
    Schiavone G, Raskovic D, Greco J, et al. Platelet-rich plasma for androgenetic alopecia: a pilot study. Dermatol Surg. 2014;40(9):1010–9.CrossRefPubMedGoogle Scholar
  23. 23.
    Sclafani AP. Platelet-rich fibrin matrix for androgenetic alopecia. Facial Plast Surg. 2014;30:219–24.CrossRefPubMedGoogle Scholar
  24. 24.
    Betsi EE, Germain E, Kalbermatten DF, et al. Platelet-rich plasma injection is effective and safe for the treatment of alopecia. Eur J Plast Surg. 2013;36:407–12.CrossRefGoogle Scholar
  25. 25.
    Takikawa M, Nakamura S, Nakamura S, et al. Enhanced effect of platelet-rich plasma containing a new carrier on hair growth. Dermatol Surg. 2011;37(12):1721–9.CrossRefPubMedGoogle Scholar
  26. 26.
    Amable PR, Carias PB, Teixeira MV, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Therapy. 2013;4:67.CrossRefGoogle Scholar
  27. 27.
    Giusti I, Rughetti A, D’Ascenzo S, et al. Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells. Transfusion. 2009;49:771–8.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of DermatologyBoston University School of MedicineBostonUSA
  2. 2.Department of Pathology and Laboratory MedicineBoston University School of MedicineBostonUSA

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