American Journal of Clinical Dermatology

, Volume 17, Issue 3, pp 225–237 | Cite as

Cutaneous T-Cell Lymphoma: A Review with a Focus on Targeted Agents

Review Article


Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of extranodal lymphomas involving the skin. Diagnosis of the two main subtypes of CTCL—mycosis fungoides (MF) and Sézary syndrome (SS)—is based on the International Society for Cutaneous Lymphomas/European Organization for Research and Treatment of Cancer (ISCL/EORTC) classification system, which utilizes clinical, histopathological, molecular biologic, and immunopathologic features. Risk stratification, based on TNMB (tumor, node, metastasis, and blood) staging, provides prognostic information, with limited-stage disease conferring the longest median overall survival. Skin-directed therapies are preferred in the management of limited-stage disease, whereas advanced-stage disease requires systemic therapies. As the mechanisms of CTCL pathogenesis are increasingly understood, new monoclonal antibodies, checkpoint inhibitors, immunomodulatory agents, and small molecules are under investigation and may provide additional therapeutic options for those with advanced CTCL. This review examines the current landscape of targeted therapies in the treatment of CTCLs.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Division of Hematology and Oncology, Department of Internal MedicineUniversity of Michigan Comprehensive Cancer CenterAnn ArborUSA
  2. 2.Division of Hematology and Oncology, Department of Internal MedicineUniversity of Michigan Comprehensive Cancer CenterAnn ArborUSA

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