American Journal of Clinical Dermatology

, Volume 15, Issue 5, pp 425–444 | Cite as

Dermatological Toxicity Associated with Targeted Therapies in Cancer: Optimal Management

  • Lucie Peuvrel
  • Brigitte Dréno
Review Article


Targeted therapies have developed rapidly over the last few years in the field of oncology thanks to a better understanding of carcinogenesis. They target pathways involved in signal transduction (EGFR, HER2, HER3, HER4, FLT3, RAS, RAF, MEK, KIT, RET, mTOR, SRC, EPH, SCF), tumor angiogenesis (VEGFR, TIE2), and tumor microenvironment (PDGFR, FGFR). They rarely cause the systemic adverse reactions generally associated with chemotherapy, but frequently cause disabling and specific skin toxicity. The impact on patient quality of life can be important both in terms of symptoms caused and of potentially aesthetic consequences. Inappropriate management can increase the risk of dose reduction or discontinuation of the cancer treatment. In this review, we will discuss skin toxicity associated with the main drug classes—EGFR, BRAF, MEK, mTOR, c-KIT, CTLA4, and SMO inhibitors, and anti-angiogenic agents. Targeted therapy-induced skin toxicities will be detailed in terms of symptoms, frequency, evolution, complications, and topical and oral treatments in order to improve their diagnosis and management.


Imatinib Sorafenib Sunitinib Dasatinib Ipilimumab 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



No sources of funding were used to prepare this review. Lucie Peuvrel and Brigitte Dréno have no conflicts of interest that are directly relevant to the content of this review.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Department of Dermato CancerologyNantes University Hospital, INSERM U892-CNRS U6299, CIC Biothérapie INSERM 0503NantesFrance

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