American Journal of Clinical Dermatology

, Volume 15, Issue 4, pp 323–337 | Cite as

A Review of Novel Therapies for Melanoma

  • Chante Karimkhani
  • Rene Gonzalez
  • Robert P. DellavalleEmail author
Review Article


This review summarizes results from major recent trials regarding novel therapeutic agents in melanoma. The topics discussed include targeted therapy with BRAF (V-RAF murine sarcoma viral oncogene homolog B) inhibitors (vemurafenib and dabrafenib), MEK (mitogen-activated protein kinase kinase) inhibitors (trametinib), bcr-abl/c-kit/PDGF-R inhibitors (imatinib), and angiogenesis inhibitors (bevacizumab and aflibercept), as well as immunotherapy with anti-CTLA-4 (anti-cytotoxic T-lymphocyte antigen-4) antibodies (ipilimumab), anti-PD (anti-programmed death receptor) antibodies (nivolumab and lambrolizumab), and anti-PD-L (anti-programmed death ligand) antibodies. Various combinations of these agents, as well as adjunctive GM-CSF (granulocyte–macrophage colony-stimulating factor), T-VEC (talimogene laherparepvec) oncolytic viruses, and novel chemotherapeutic agents, are also described. Despite the tremendous advances that these novel treatments have created, optimal therapeutic agent selection remains a highly individualized decision. Melanoma therapy has vastly progressed since the days when dacarbazine was the sole option for advanced melanoma patients. The molecular understanding of melanoma pathogenesis has yielded a brighter future for advanced melanoma patients.


Melanoma Bevacizumab Imatinib Dasatinib BRAF Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to express their thanks to Chanel Karimkhani, who designed the figures included in this article No sources of funding were used in the preparation of this article, and the authors have no financial or other conflicts of interest to declare.


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Copyright information

© Springer International Publishing Switzerland (outside the USA) 2014

Authors and Affiliations

  • Chante Karimkhani
    • 1
  • Rene Gonzalez
    • 2
  • Robert P. Dellavalle
    • 3
    • 4
    • 5
    Email author
  1. 1.Columbia University College of Physicians and SurgeonsNew YorkUSA
  2. 2.University of Colorado Cancer CenterAuroraUSA
  3. 3.Department of DermatologyUniversity of Colorado DenverAuroraUSA
  4. 4.Department of EpidemiologyColorado School of Public HealthAuroraUSA
  5. 5.Dermatology ServiceDepartment of Veterans Affairs Medical CenterDenverUSA

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