American Journal of Clinical Dermatology

, Volume 14, Issue 6, pp 429–435 | Cite as

Immunotherapy for Acne Vulgaris: Current Status and Future Directions

  • Thierry SimonartEmail author
Leading Article


There is a high unmet clinical need for new and better treatments in acne vulgaris. Propionibacterium acnes has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity, keratinocytes and sebaceous glands of the pilosebaceous follicle. The role of P. acnes in acne confers legitimacy on the possible benefits of immunization-based approaches, which may represent a solution for limiting the development of antibiotic-resistant P. acnes. Various immunization-based approaches have been developed over the last decades, including killed pathogen-based vaccines, vaccination against cell wall-anchored sialidase, monoclonal antibodies to the Christie, Atkins, Munch-Peterson factor of P. acnes, anti-Toll-like receptors vaccines and natural antimicrobial peptides. This review summarizes the current evidence and explores the challenges to making this a realistic treatment option for the future.


Acne Isotretinoin Adapalene Acne Lesion Acne Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



No sources of funding were used to prepare this review.

Conflicts of interest

The author has no conflicts of interest to disclose.


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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  1. 1.BrusselsBelgium

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