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American Journal of Clinical Dermatology

, Volume 14, Issue 1, pp 49–53 | Cite as

Principal Determinants of the Length of Remission of Psoriasis Vulgaris After Topical, NB-UVB, and PUVA Therapy

A Follow-Up Study
  • Susana Coimbra
  • Hugo Oliveira
  • Luís Belo
  • Américo Figueiredo
  • Petronila Rocha-Pereira
  • Alice Santos-Silva
Short Communication

Abstract

Background

Periods of remission and of exacerbation of psoriatic lesions are common in psoriasis. We recently reported C-reactive protein (CRP) as a marker of psoriasis severity and that some patients still presented with a residual inflammation after treatment. We wondered if this residual inflammation could underlie an earlier exacerbation of psoriasis.

Objective

The purpose of our study was to evaluate if there is a relationship between CRP levels, Psoriasis Area and Severity Index (PASI), and body mass index (BMI), at the end of psoriasis treatment, with the length of psoriasis remission.

Methods

We followed 46 patients studied at the end of treatment, to record the length of remission; 9 of the patients were treated with topical agents, 17 with narrow-band UVB (NB-UVB), and 20 with psoralen plus UVA (PUVA).

Results

We found that the length of remission correlated with the values for PASI and CRP at the end of therapy. By performing a multiple linear regression analysis, CRP, PASI, and BMI were each significantly associated with length of remission. Patients with residual inflammation at the end of treatment presented with a significantly shorter length of remission. When considering patients grouped according to the used therapies, CRP and PASI also emerged as potential determinants of length of remission, especially in the case of patients treated with NB-UVB and topical therapy.

Conclusion

Our data suggest that CRP and PASI are important determinants of length of psoriasis remission for patients treated with phototherapy or topical therapy. Further studies with larger groups of patients are warranted to test this hypothesis. Moreover, we propose that, by the end of the treatment, the evaluation of CRP and PASI could be important to decide, when possible, if the treatment should be continued to achieve lower CRP values and longer periods of remission.

Keywords

Psoriasis Multiple Linear Regression Analysis Topical Agent Topical Therapy Calcipotriol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This study was supported by Fundação para a Ciência e Tecnologia (FCT: POCI/SAU–OBS/58600/2004) and Fundo Europeu de Desenvolvimento Regional (FEDER). The authors have no financial or other relations that could lead to conflict of interest; all authors state no conflict of interest.

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Copyright information

© Springer International Publishing Switzerland 2012

Authors and Affiliations

  • Susana Coimbra
    • 1
    • 2
  • Hugo Oliveira
    • 3
  • Luís Belo
    • 1
    • 4
  • Américo Figueiredo
    • 3
  • Petronila Rocha-Pereira
    • 1
    • 5
  • Alice Santos-Silva
    • 1
    • 4
  1. 1.Instituto de Biologia Molecular e Celular (IBMC)Universidade do PortoPortoPortugal
  2. 2.Centro de Investigação das Tecnologias da Saúde (CITS)Instituto Politécnico da Saúde Norte (IPSN)-CESPUGandra-ParedesPortugal
  3. 3.Serviço de DermatologiaHospitais da Universidade de CoimbraCoimbraPortugal
  4. 4.Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de FarmáciaUniversidade do PortoPortoPortugal
  5. 5.Centro de Investigação em Ciências da Saúde (CICS)Universidade da Beira InteriorCovilhãPortugal

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