Value of Galectin-3 in Acute Myocardial Infarction
Galectins are an ancient family of lectins characterized by evolutionarily conserved amino acid sequences and β-galactoside recognition and binding sites. Galectin-3 (Gal-3) is one of 15 known galectins. This protein has important functions in numerous biological activities, including cardiac fibrosis and heart failure. In recent years, many studies have shown that Gal-3 is closely associated with acute myocardial infarction (AMI) and may be a promising biomarker for the assessment of severity as well as prognosis prediction in AMI patients, but controversy still exists. In this review, we summarize the latest literature on the relationship between Gal-3 and unstable plaques, the secretion kinetics of Gal-3 during the acute phase of AMI, and the value of Gal-3 in the prediction of post-AMI remodeling. Finally, the possible value of Gal-3 as a biological target for AMI therapy is examined.
The authors thank Dr. Kai Guo for assistance with figure preparation.
ML performed the literature search and wrote the article; KG and YL contributed to the figure preparation; YY and XH provided a good suggestion regarding the subject matter of the paper; and LF reviewed and approved the manuscript.
Compliance with Ethical Standards
No sources of funding were used to assist in the preparation of this review.
Conflict of interest
Mingxing Li, Yong Yuan, Kai Guo, Yi Lao, Xuansheng Huang, Li Feng declare they have no conflicts of interest.
- 1.Mendis S, Puska P, Norrving B. Global atlas on cardiovascular disease prevention and control. Geneva: World Health Organization; 2011.Google Scholar
- 3.McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European society of cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2012;14:803–69.PubMedCrossRefGoogle Scholar
- 13.Lopez-Andrès N, Rossignol P, Iraqi W, Fay R, Nuée J, Ghio S, et al. Association of galectin-3 and fibrosis markers with long-term cardiovascular outcomes in patients with heart failure, left ventricular dysfunction, and dyssynchrony: insights from the CARE-HF (CArdiac REsynchronization in Heart Failure) trial. Eur J Heart Fail. 2011;14:74–81.PubMedCrossRefGoogle Scholar
- 16.Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;128:240–327.Google Scholar
- 40.Yalta K, Yilmaz MB, Yalta T, Palabiyik O, Taylan G, Zorkun C. Late versus early myocardial remodeling after acute myocardial infarction: a comparative review on mechanistic insights and clinical implications. J Cardiovasc Pharmacol Ther. 2019. https://doi.org/10.1177/1074248419869618.CrossRefPubMedGoogle Scholar
- 45.Dong R, Zhang M, Hu Q, Zheng S, Soh A, Zheng Y, et al. Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review). Int J Mol Med. 2018;41:599–614.Google Scholar
- 73.Lisowska A, Knapp M, Tycińska A, Motybel E, Kamiński K, Święcki P, et al. Predictive value of Galectin-3 for the occurrence of coronary artery disease and prognosis after myocardial infarction and its association with carotid IMT values in these patients: a mid-term prospective cohort study. Atherosclerosis. 2016;246:309–17.PubMedCrossRefGoogle Scholar
- 76.Martín-Reyes R, Franco-Peláez JA, Lorenzo Ó, González-Casaus ML, Pello AM, Aceña Á, et al. Plasma levels of monocyte chemoattractant protein-1, n-terminal fragment of brain natriuretic peptide and calcidiol are independently associated with the complexity of coronary artery disease. PLoS One. 2016;11:e0152816.PubMedPubMedCentralCrossRefGoogle Scholar
- 78.Szadkowska I, Wlazeł RN, Migała M, Szadkowski K, Zielińska M, Paradowski M, et al. The association between galectin-3 and clinical parameters in patients with first acute myocardial infarction treated with primary percutaneous coronary angioplasty. Cardiol J. 2013;20:577–82.PubMedCrossRefGoogle Scholar