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Fabrication of Mesoporous SiO2@CaSiO3 Hollow Spheres as Carriers for pH-sensitive Drug Delivery

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Abstract

Hollow mesoporous silica(HM-SiO2) was prepared by the improved stober method. On this basis, HM-SiO2 was dispersed in an alkaline solution for surface etching. Meanwhile, calcium source was introduced to combine with SiO 2−3 on the surface to form a CaSiO3 shell layer and an unprecedent SiO2@CaSiO3 sphere with a hollow double-shell structure was obtained. The as-synthesized SiO2@CaSiO3 was characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), N2-BET, IR and UV-Vis techniques, and its sustained release capacity of doxorubicin(DOX) loading was investigated. The drug loading capacity can be achieved to 0.692 mg DOX/mg SiO2@CaSiO3, exhibiting pH-responsivity under low pH conditions.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No.21961021) and the Natural Science Foundation of Jiangxi Province, China (No.20202ACB203001).

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Authors and Affiliations

  1. Key Laboratory of Jiangxi Province for Environment and Energy Catalysis, College of Chemistry, Nanchang University, Nanchang, 330031, P. R. China

    Mingwei Yuan, Shunli Shi, Yanping Luo, Ying Yu, Shuhua Wang & Chao Chen

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  1. Mingwei Yuan
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  2. Shunli Shi
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  3. Yanping Luo
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  4. Ying Yu
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  5. Shuhua Wang
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  6. Chao Chen
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Correspondence to Shuhua Wang or Chao Chen.

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The authors declare no conflicts of interest.

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Yuan, M., Shi, S., Luo, Y. et al. Fabrication of Mesoporous SiO2@CaSiO3 Hollow Spheres as Carriers for pH-sensitive Drug Delivery. Chem. Res. Chin. Univ. 38, 999–1004 (2022). https://doi.org/10.1007/s40242-021-1248-6

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  • DOI: https://doi.org/10.1007/s40242-021-1248-6

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