Chemical Research in Chinese Universities

, Volume 35, Issue 4, pp 686–692 | Cite as

Fabrication and In vitro Bioactivity of Robust Hydroxyapatite Coating on Porous Titanium Implant

  • Mengna Duan
  • Xiaofeng Wu
  • Long Yuan
  • Zhiying Zhang
  • Yan Zhang
  • Yanmin ZhouEmail author


Compared with the traditional dental implant, TixOs® manufactured by direct laser metal forming(DLMF) technology exhibits improved capability for bone osteointegration due to its porous surface structure, and has achieved remarkable clinical effect. However, like the traditional titanium and other alloyed implants, the porous titanium implant TixOs® also has relatively weak bioactivity. To address this issue, a proper surface modification method may be needed. Hydroxyapatite(HA) has been widely used in implant surface coating for its similar chemical composition to bone tissue and its osteoconductive properties. Thus, combining TixOs® implants with hydroxyapatite can be an efficient way to enhance their bioactivity. We herewith reported a competent pulsed laser deposition(PLD) method of coating nano-sized HA thin film onto the porous TixOs® implant. The HA coatings were characterized by means of scanning electron microscopy(SEM), energy dispersive X-ray spectroscopy(EDS), X-ray photoelectron spectroscopy(XPS) and focused ion beam(FIB) method, and nanocrystal sized thin HA films were identified on the surface of TixOs® implants. The low cytotoxicity and improved cell proliferation ability of HA coated implants were further tested and verified using MC 3T3 E1 cells with the consideration of the controlling group. Our results show that a stable and bioactive HA thin film is able to form on the surface of the porous titanium implant by PLD method. This may benefit the further clinical application of TixOs® implants.


Hydroxyapatite Pulsed laser deposition Porous titanium Bioactivity 


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The authors would like to thank the Company of Leader-Novaxa(Italia) for providing TixOs® implants for free.


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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2019

Authors and Affiliations

  • Mengna Duan
    • 1
  • Xiaofeng Wu
    • 2
  • Long Yuan
    • 3
  • Zhiying Zhang
    • 1
  • Yan Zhang
    • 1
  • Yanmin Zhou
    • 1
    Email author
  1. 1.Hospital of StomatologyJilin UniversityChangchunP. R. China
  2. 2.State Key Laboratory of Inorganic Synthesis & Preparative ChemistryJilin UniversityChangchunP. R. China
  3. 3.Key Laboratory of Functional Materials Physics and Chemistry, Ministry of EducationJilin Normal UniversityChangchunP. R. China

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