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Dissipative Particle Dynamics Study on Platycodin’s Solubilization Enhancing Effect Towards Five Drug Components

  • Zhimin Wu
  • Haiou Ding
  • Chang Yang
  • Shujuan Guo
  • Xingxing Dai
  • Xinyuan ShiEmail author
Article
  • 5 Downloads

Abstract

In this study, a dissipative particle dynamics mehtod was used to study the solubilization enhancing effect of platycodin towards 5 different drug components. Two factors were mainly considered, including the XlogP value of drug components and the sugar chain length of platycodin. As a result, it was found that there was an optimal drug XlogP value for the solubilization enhancing effect of platycodin, and it was different between the drug’s own XlogP value and the optimal drug XlogP value of platycodin that determines the solubilization enhancing effect.

Keywords

Platycodin Dissipative particle dynamics Solubilization enhancing effect XlogP 

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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Zhimin Wu
    • 1
    • 2
  • Haiou Ding
    • 1
    • 2
  • Chang Yang
    • 1
  • Shujuan Guo
    • 1
  • Xingxing Dai
    • 1
    • 2
  • Xinyuan Shi
    • 1
    • 2
    Email author
  1. 1.Traditional Chinese Medicine InstituteBeijing University of Chinese MedicineBeijingP. R. China
  2. 2.Beijing Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese MedicineBeijing Municipal Science & Technology CommissionBeijingP. R. China

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