A Highly Efficient and Recyclable Solid Acid Catalyst for Synthesis of Spiro-oxindole Dihydroquinazolinones Under Ultrasound Irradiation

  • Xiufang Yang
  • Xiaogang Wang
  • Tingting Wang
  • Weitao Wang
  • Jin Zhang
  • Yangmin Ma


A simple, efficient and green procedure for the synthesis of spiro-oxindole dihyfroquinazolinones was developed by multi-component condensation of isatoic anhydride, aniline and isatin in the presence of a novel solid acid catalyst under ultrasound irradiation. The present environmentally benign protocol offers several advantages, such as shorter reaction time, a wide range of functional group tolerance, the use of an inexpensive heterogeneous catalyst, and a high yield of products via a simple experimental and work-up procedure. The mesoporous solid acid catalyst was directly prepared from phytic acid by microwave-sulfonation method without template. The phytic acid based solid acid was fully characterized by means of Fourier transform infrared spectroscopy(FTIR), Raman spec-troscopy, X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS), and transmission electron microsco-py(TEM). The catalyst can be recovered and reused for at least five runs without significant impact on the product yields.


Microwave-sulfonation method Solid acid catalyst Spiro-oxindole dihyfroquinazolinone 


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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of Chemistry & Chemical EngineeringShaanxi University of Science and TechnologyXi’anP. R. China
  2. 2.Shaanxi Key Laboratory of Chemical Additives for IndustryShaanxi University of Science and TechnologyXi’anP. R. China
  3. 3.Shaanxi Research Institute of Agricultural Products Processing TechnologyShaanxi University of Science and TechnologyXi’anP. R. China

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