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Chemical Research in Chinese Universities

, Volume 34, Issue 6, pp 923–928 | Cite as

Facile Synthesis of 1,5-Diaryl-4-pyridyl-1,2,3-triaozle Derivatives

  • Yingnan Wang
  • Chiyu Wei
  • Zhiguang Song
Article
  • 13 Downloads

Abstract

A feasible approach to synthesize 1,5-diaryl-4-pyridyl-1,2,3-triaozle via a sequential route from 2-alkynyl pyridine was developed. In this work, KOH was identified as a crucial base to promote the Pd-catalyzed arylation step. Compared to the reported methods, this protocol largely improved the reaction efficiency with overall excellent yield and good functional group tolerance.

Keywords

1,2,3-Triazole Arylation Triazole ligand 

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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Organic Chemistry, College of ChemistryJilin UniversityChangchunP. R. China

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