Advertisement

Chemical Research in Chinese Universities

, Volume 34, Issue 5, pp 732–735 | Cite as

Structure and Activity of a New Sapogenin from Chlorophytum laxum R. Br.

  • Chenliang Chu
  • Ting Cui
  • Sida Li
  • Ruoting Zhan
  • Youheng Gao
Article

Abstract

A new steroidal sapogenin named 25-R-spirosta-3,5-dien-12β-ol(1) was isolated from the dried roots of Chlorophytum laxum R. Br. along with five known compounds, namely, diosgenin(2), stigmasterol(3), β-sitosterols(4), estigmasterol-3-O-β-D-glicopyranoside(5) and 3-O-β-authemisol(6). The structure of compound 1 was elucidated by the analysis of IR, HRESI-MS, 1D and 2D NMR spectral data. Compounds 25 were isolated from Chlorophytum laxum R. Br. In addition, all the compounds were evaluated for cytotoxicity on the human nasopharyngeal carcinoma cancer cell line 5-8F. Among them, the newly identified 25-R-spirosta-3,5-dien-12β-ol(1) and diosgenin(2) exhibited high cytotoxicity on 5-8F cells, with IC50 values of 24.8 and 41.9 μmol/L, respectively.

Keywords

Chlorophytum laxum R. Br. Steroidal sapogenin Cytotoxicity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Notes

Acknowledgements

We gratefully acknowledge the support from Dr. PAN Chaomei of Department of Traditional Chinese Medicine Resource Center, Guangzhou University of Chinese Medicine (China).

References

  1. [1]
    Li X. C., Wang D. Z., Yang C. R., Phytochemistry, 1990, 29, 3893CrossRefGoogle Scholar
  2. [2]
    Kaushik N., Phytochemistry Reviews, 2005, 4, 191CrossRefGoogle Scholar
  3. [3]
    Jiangsu New Medical College, Dictionary of Chinese Materia Medica, Shanghai People Press, Shanghai, 1977, 62Google Scholar
  4. [4]
    Wu H. F., Mei Q. X., Diao Y. M., Journal of Chinese Medicinal Materials, 2004, 27(4), 259Google Scholar
  5. [5]
    Turibio K. T., Anne C., Mitaine O., Thomas P., Phytochemistry, 2016, 7, 1Google Scholar
  6. [6]
    Debabrata A., Anne C., Mitaine O., Nutan K., Journal of Natural Products, 2010, 73, 7CrossRefGoogle Scholar
  7. [7]
    Deore S. L., Khadabadi S. S., Pharmacognosy Journal, 2010, 2(16), 33CrossRefGoogle Scholar
  8. [8]
    Mei Q. X., Gao Y. Q., Zhong X. W., China Journal of Chinese Mate-ria Medical, 2011, 34(11), 1760Google Scholar
  9. [9]
    Liu X. X., Wang L., Ying L., China Journal of Chinese Materia Medical, 2014, 39(16), 3107Google Scholar
  10. [10]
    Liu X. Y., Xie Y. F., Zhang H., Chinese Journal of Experimental Tra-ditional Medical Formulae, 2014, 20(6), 43Google Scholar
  11. [11]
    Umlauf D., Zapp J., Becker H., Phytochemistry, 2004, 65, 2463CrossRefPubMedGoogle Scholar
  12. [12]
    Hnrd C., Mcd S., Afdl A., Quimica Nova, 2008, 31(4), 744CrossRefGoogle Scholar
  13. [13]
    Wang J., Ma Y. M., Yan M. R., Journal of Chinese Medicinal Mate-rials, 2015, 38(10), 2098Google Scholar
  14. [14]
    Xiao C. H., Chemistry of Chinese Materia Medica, Shanghai Scien-tific and Technical Publisher, Shanghai, 1994, 394Google Scholar
  15. [15]
    Harrison I. T., Velasco M., Djerassi C., Journal of Organic Chemistry, 1961, 26, 155CrossRefGoogle Scholar
  16. [16]
    Pawan K., Magnetic Resonance in Chemistry, 2004, 42, 990CrossRefGoogle Scholar
  17. [17]
    Rothman E. S., Wall M. E., Eddy C. R., J. Am. Chem. Soc., 1952, 74(16), 4013CrossRefGoogle Scholar
  18. [18]
    Liao P. F., Dong J. H., Fan J. Z., West China Journal of Pharmaceutical Sciences, 2013, 28(4), 364Google Scholar
  19. [19]
    Miao Y. N., Mei Q. X., Chen M. C., Journal of Emergency in Tradi-tional Chinese Medicine, 2005, 14(5), 429Google Scholar

Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Chenliang Chu
    • 1
  • Ting Cui
    • 1
  • Sida Li
    • 1
  • Ruoting Zhan
    • 1
  • Youheng Gao
    • 1
  1. 1.School of Pharmaceutical SciencesGuangzhou University of Chinese MedicineGuangzhouP. R. China

Personalised recommendations