Chemical Research in Chinese Universities

, Volume 34, Issue 4, pp 536–540 | Cite as

A Highly Selective and Sensitive Ratiometric Fluorescent Probe for Hypochlorite and Its Application

  • Longqi Xue
  • Yusha Feng
  • Yan Song
  • Rui Wang
  • Dahai Liu
  • Jianshi Du
  • Qingbiao Yang
  • Yaoxian Li


A novel water-soluble hybrid fluorescein-coumarin dye(FLNC) fluorescence ratiometric probe to recognize OCl was designed and synthesized. The most prominent feature of the probe is that the molecular structure contains two different fluorophores, and the fluorescein moiety was connected to coumarin moiety by diacylhydrazine linker. When OCl was added, the two fluorophores in the FLNC probe could have a rapid respond simultaneously, with high selectivity and sensitivity towards OCl among other reactive oxygen species/reactive nitrogen species(ROS/RNS) and anions, and the detection limit was measured to be 0.30 μmol/L. In addition, the color changes of the solution could be observed by the naked eye and have a short response time(completed within 1 min), which suggestes that the probe FLNC has the potential to be used for real-time detection.


Fluorescent probe Dual-fluorophore Ratiometric Hypochlorite 


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Supplementary material

40242_2018_8028_MOESM1_ESM.pdf (598 kb)
Electronic Supplementary Information


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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Longqi Xue
    • 1
    • 2
  • Yusha Feng
    • 2
    • 3
  • Yan Song
    • 3
  • Rui Wang
    • 2
  • Dahai Liu
    • 1
  • Jianshi Du
    • 1
  • Qingbiao Yang
    • 2
  • Yaoxian Li
    • 2
  1. 1.China-Japan Union HospitalJilin UniversityChangchunP. R. China
  2. 2.College of ChemistryJilin UniversityChangchunP. R. China
  3. 3.College of Materials Science and EngineeringJilin University of Chemical TechnologyJilinP. R. China

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