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Chemical Research in Chinese Universities

, Volume 34, Issue 4, pp 584–589 | Cite as

CXCR4 Peptide Conjugated Au-Fe2O3 Nanoparticles for Tumor-targeting Magnetic Resonance Imaging

  • Guifeng Liu
  • Hongda Chen
  • Shaonan Yu
  • Xiaodong Li
  • Zhenxin Wang
Article
  • 15 Downloads

Abstract

Peptide-functionalized Au-Fe2O3 nanoparticles(termed as anti-CXCR4-Au-Fe2O3 NPs) have been constructed through conjugation of dumbbell-like Au-Fe2O3 NPs with C-X-C motif chemokine receptor 4(CXCR4) binding cyclic peptide. One dumbbell-like Au-Fe2O3 NP composes an Au NP[(3.3±0.3) nm in diameter] for conjugating CXCR4 binding cyclic peptide through Au-S covalent bond and a Fe2O3 NP[(8.7±0.8) nm in diameter] for using as T2-weighted magnetic resonance imaging(MRI) contrast agent. The anti-CXCR4-Au-Fe2O3 NPs have reasonable biocompatibility and integration of T2-weighted MRI contrast and tumor-targeting functionalities. The anti-CXCR4-Au-Fe2O3 NPs exhibit strong interactions with two kinds of breast tumor cells, MCF-7 cells and MDA-MB-231 cells, and high negative contrast in MRI of MDA-MB-231 tumor bearing mouse with 62% decreasing of MRI signal, indicating that the anti-CXCR4-Au-Fe2O3 NPs can recognize tumor with high efficacy and specificity.

Keywords

Dumbbell-like Au-Fe2O3 nanoparticle C-X-C motif chemokine receptor 4 Cyclic peptide T2-Weighted magnetic resonance imaging Tumor targeting ability 

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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Guifeng Liu
    • 1
  • Hongda Chen
    • 2
  • Shaonan Yu
    • 1
  • Xiaodong Li
    • 3
  • Zhenxin Wang
    • 2
  1. 1.Department of RadiologyChina-Japan Union Hospital of Jilin UniversityChangchunP. R. China
  2. 2.State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunP. R. China
  3. 3.Department of Radiologythe First Hospital of Jilin UniversityChangchunP. R. China

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