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Chemical Research in Chinese Universities

, Volume 34, Issue 2, pp 197–202 | Cite as

Microwave-assisted Synthesis of New 1,2,3-Triazoles Bearing an Isoxazole Ring by the Azide-alkyne Cycloaddition Click Chemistry

  • Jing Li
  • Hongwei Liu
  • Fanyu Meng
  • Liuqing Yan
  • Yanpeng Shi
  • Yumin Zhang
  • Qiang Gu
Article
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Abstract

A comparison synthesis of 1,2,3-triazoles bearing isoxazole ether was developed between conventional and microwave-assisted heating. Single/double 1,2,3-triazoles bearing isoxazole ether were synthesized by click reaction starting from substituted isoxazolyl alkyne compounds and substituted benzyl azide compounds or neopen-tylglycol diazide in the presence of copper(I) that in-situ generated. Herein, the effect of different catalysts on the yield was researched by conventional method, and the optimal catalyst was selected. The structures of all the synthe-sized compounds were confirmed by MS, FTIR, 1H and 13C NMR spectroscopies. Moreover, the crystal structure of 5-{[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]methyl}-3-(4-fluorophenyl)isoxazole(2h) was determined.

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Keywords

Microwave-assisted heating 1,2,3-Triazole Isoxazole Azide-alkyne Click chemistry 
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Supplementary material

40242_2018_7298_MOESM1_ESM.pdf (1.7 mb)
Microwave-assisted synthesis of new 1,2,3-triazoles bearing an isoxazole ring by the azide-alkyne cycloaddition click chemistry

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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jing Li
    • 1
  • Hongwei Liu
    • 1
  • Fanyu Meng
    • 1
  • Liuqing Yan
    • 1
  • Yanpeng Shi
    • 1
  • Yumin Zhang
    • 1
    • 2
  • Qiang Gu
    • 1
    • 2
  1. 1.College of ChemistryJilin UniversityChangchunP. R. China
  2. 2.National-Local Joint Engineering Laboratory of In-situ ConversionDrilling and Exploitation Technology for Oil ShaleChangchunP. R. China

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