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Chemical Research in Chinese Universities

, Volume 30, Issue 6, pp 941–946 | Cite as

Synthesis of resveratrol analogs/stilbene derivatives and their nitric oxide inhibitory and radical scavenging activities

  • Jue Wang
  • Cunlong Zhang
  • Tiejie Wang
  • Xiaofan Li
Article

Abstract

Sixteen resveratrol analogs(stilbene derivatives) including resveratrol were synthesized, in which hydroxystilbenes, naturally occurring polyphenols, showed protective effects against reactive oxygen and nitrogen species(ROS/RNS) and hexahydroxystilbene(16) displayed the strongest activities against NO and 1,1-diphenyl-2-picrylhydrazyl(DPPH) with IC50 values of 7.8 and 5.7 μmol/L, respectively.

Keywords

Resveratrol Stilbene Nitric oxide Radical 

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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2014

Authors and Affiliations

  • Jue Wang
    • 1
  • Cunlong Zhang
    • 3
  • Tiejie Wang
    • 1
  • Xiaofan Li
    • 2
  1. 1.Shenzhen Institute for Drug ControlShenzhenP. R. China
  2. 2.Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life SciencesShenzhen UniversityShenzhenP. R. China
  3. 3.Shenzhen Key Laboratory of Chemical Biology, Graduate School at ShenzhenTsinghua UniversityShenzhenP. R. China

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