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Journal of Diabetes & Metabolic Disorders

, Volume 18, Issue 1, pp 119–125 | Cite as

Effects of ginger supplementation on anthropometric, glycemic and metabolic parameters in subjects with metabolic syndrome: A randomized, double-blind, placebo-controlled study

  • Mehran Rahimlou
  • Zahra Yari
  • Elham Rayyani
  • Seyed Ali Keshavarz
  • Seyedahmad Hosseini
  • Nava Morshedzadeh
  • Azita HekmatdoostEmail author
Research Article

Abstract

Background

Metabolic syndrome (MetS) is one of the worldwide most chronic endocrine disorders. The disease can also lead to several other chronic disorders such as type 2 diabetes mellitus, cardiovascular diseases, renal diseases and cancers. This study aimed to evaluate the safety and efficacy of ginger powder on biochemical and anthropometric parameters in patients with MetS.

Methods

This randomized controlled clinical trial was conducted on 37 patients with MetS. We supplemented the individuals with MetS with either 2 g per day ginger powder or placebo for 12 weeks. Biochemical and anthropometric parameters before and after the intervention were compared between the two groups.

Results

After 12 weeks of treatment, the levels of triglyceride (TG), FBS, and insulin resistance were significantly improved in the patients receiving ginger in compare to the placebo group (P < 0·05). Moreover, significant changes were observed in terms of weight, waist circumference, LDL, HDL, total cholesterol, systolic and diastolic blood pressure and energy intake between the groups.

Conclusion

In general, our findings demonstrated that the ginger supplementation offers beneficial effects on patients with MetS, at least, in part due to the modulatory effects on TG, FBS, and insulin resistance.

Keywords

Ginger Metabolic syndrome Insulin resistance Lipid profile 

Notes

Acknowledgements

This study was supported by a grant from the Tehran Medical University. We hereby appreciate the participation of the patients as well as the cooperation of the staff at the National Nutrition and Food Technology Research Institute of the Shahid Beheshti University. We also appreciate Mr. Mousa Vatanmakanian for the critical revision and language editing of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors disclose no conflicts of interest.

References

  1. 1.
    Grundy SM. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab. 2004;89:2595–600.CrossRefPubMedGoogle Scholar
  2. 2.
    Engin A. The definition and prevalence of obesity and metabolic syndrome. Adv Exp Med Biol. 2017;960:1–17.CrossRefPubMedGoogle Scholar
  3. 3.
    Karimi N, Dabidi Roshan V, Fathi BZ. Individually and combined water-based exercise with ginger supplement, on systemic inflammation and metabolic syndrome indices, among the obese women with breast neoplasms. Iran J Cancer Prev. 2015;8:e3856.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Panickar KS. Beneficial effects of herbs, spices and medicinal plants on the metabolic syndrome, brain and cognitive function. Cent Nerv Syst Agents Med Chem. 2013;13:13–29.CrossRefPubMedGoogle Scholar
  5. 5.
    Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. J Complement Integr Med. 2015;12:165–70.CrossRefPubMedGoogle Scholar
  6. 6.
    Wei CK, Tsai YH, Korinek M, Hung PH, El-Shazly M, Cheng YB, et al. 6-Paradol and 6-Shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and Myotubes, and 6-Paradol reduces blood glucose in high-fat diet-fed mice. Int J Mol Sci. 2017;18.Google Scholar
  7. 7.
    Suk S, Seo SG, Yu JG, Yang H, Jeong E, Jang YJ, et al. A bioactive constituent of ginger, 6-Shogaol, prevents Adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes. J Food Biochem. 2016;40:84–90.CrossRefGoogle Scholar
  8. 8.
    Li Y, Tran VH, Kota BP, Nammi S, Duke CC, Roufogalis BD. Preventative effect of Zingiber officinale on insulin resistance in a high-fat high-carbohydrate diet-fed rat model and its mechanism of action. Basic Clin. Pharmacol. Toxicol. 2014;115:209–15.CrossRefPubMedGoogle Scholar
  9. 9.
    Nammi S, Sreemantula S, Roufogalis BD. Protective effects of ethanolic extract of Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats. Basic Clin Pharmacol Toxicol. 2009;104:366–73.CrossRefPubMedGoogle Scholar
  10. 10.
    Expert Panel on Detection E. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285:2486.CrossRefGoogle Scholar
  11. 11.
    Alizadeh-Navaei R, Roozbeh F, Saravi M, Pouramir M, Jalali F, Moghadamnia AA. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Medical Journal. 2008;29:1280–4.PubMedGoogle Scholar
  12. 12.
    Initiative NOE, Heart N, Lung, Institute B, Obesity NAAftSo, Identification EPot, et al. The practical guide: identification, evaluation, and treatment of overweight and obesity in adults: The Institute; 2000.Google Scholar
  13. 13.
    Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000;32:S498–504.CrossRefPubMedGoogle Scholar
  14. 14.
    Hardy R, Kuh D, Langenberg C, Wadsworth ME. Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort. Lancet (London, England). 2003;362:1178–83.CrossRefGoogle Scholar
  15. 15.
    Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.CrossRefPubMedGoogle Scholar
  16. 16.
    Hrebicek J, Janout V, Malincikova J, Horakova D, Cizek L. Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. Journal of Clinical Endocrinology & Metabolism. 2002;87:144–7.CrossRefGoogle Scholar
  17. 17.
    Shanmugam KR, Mallikarjuna K, Kesireddy N, Sathyavelu RK. Neuroprotective effect of ginger on anti-oxidant enzymes in streptozotocin-induced diabetic rats. Food Chem Toxicol. 2011;49:893–7.CrossRefPubMedGoogle Scholar
  18. 18.
    Arablou T, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. Int J Food Sci Nutr. 2014;65:515–20.CrossRefPubMedGoogle Scholar
  19. 19.
    Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr. 2013;64:682–6.CrossRefPubMedGoogle Scholar
  20. 20.
    Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr. 2006;96:660–6.CrossRefPubMedGoogle Scholar
  21. 21.
    Li Y, Tran VH, Duke CC, Roufogalis BD. Preventive and protective properties of Zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review. Evid Based Complement Alternat Med. 2012;2012:516870.PubMedPubMedCentralGoogle Scholar
  22. 22.
    Henriksen EJ. Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes. Free Radic Biol Med. 2006;40:3–12.CrossRefPubMedGoogle Scholar
  23. 23.
    Mahmoud RH, Elnour WA. Comparative evaluation of the efficacy of ginger and orlistat on obesity management, pancreatic lipase and liver peroxisomal catalase enzyme in male albino rats. Eur Rev Med Pharmacol Sci. 2013;17:75–83.PubMedGoogle Scholar
  24. 24.
    Brahma Naidu P, Uddandrao VV, Ravindar Naik R, Suresh P, Meriga B, Begum MS, et al. Ameliorative potential of gingerol: promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats. Mol Cell Endocrinol. 2016;419:139–47.CrossRefPubMedGoogle Scholar
  25. 25.
    Gao H, Guan T, Li C, Zuo G, Yamahara J, Wang J, et al. Treatment with ginger ameliorates fructose-induced fatty liver and hypertriglyceridemia in rats: modulation of the hepatic carbohydrate response element-binding protein-mediated pathway. Evid Based Complement Alternat Med. 2012;2012:570948.PubMedPubMedCentralGoogle Scholar
  26. 26.
    Azimi P, Ghiasvand R, Feizi A, Hosseinzadeh J, Bahreynian M, Hariri M, et al. Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. Blood Press. 2016;25:133–40.CrossRefPubMedGoogle Scholar
  27. 27.
    Mozaffari-Khosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med. 2014;22:9–16.CrossRefPubMedGoogle Scholar
  28. 28.
    Ebrahimzadeh Attari V, Ostadrahimi A, Asghari Jafarabadi M, Mehralizadeh S, Mahluji S. Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT. Eur J Clin Nutr. 2016;55:2129–36.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mehran Rahimlou
    • 1
    • 2
  • Zahra Yari
    • 3
  • Elham Rayyani
    • 1
  • Seyed Ali Keshavarz
    • 1
  • Seyedahmad Hosseini
    • 2
  • Nava Morshedzadeh
    • 3
  • Azita Hekmatdoost
    • 3
    Email author
  1. 1.Department of Clinical Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical Sciences (TUMS)TehranIran
  2. 2.School of ParamedicineAhvaz Jundishapur University of Medical SciencesAhvazIran
  3. 3.Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research InstituteShahid Beheshti University of Medical ScienceTehranIran

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