Prothrombin time, activated partial thromboplastin time and platelet counts of type II diabetes mellitus: a comparative study
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The incidence of cardiovascular disease due to thrombosis is 2–4 folds greater in diabetic patients. Prothrombin time, activated partial thromboplastin time and platelet count are hematological indices that give an insight into the coagulation status. Hence, this study aims to assess the coagulation status of type II diabetic patients.
A comparative cross-sectional study was conducted at Bahir Dar Felege Hiwot referral hospital, Northwest Ethiopia. A total of 40 treated type II diabetic, 40 untreated diabetics and 40 non-diabetic subjects were included. After taking informed consent, structured questionnaire was used to collect socio-demographic data. Following interview, 4 ml of blood was collected to determine PT, aPTT and platelet count of the three groups. The data were entered into SPSS version 20 and analyzed. One-way ANOVA was used to compare means of PT, aPTT and platelet count among the groups. A P value less than 0.05 was considered as statistically significant.
The mean aPTT of non-diabetic, treated and untreated type II diabetic patient was 32.8 ± 4.12 s, 34.4 ± 5.3 s, and 25.42 ± 8.46 s, respectively. The proportion of untreated diabetic patients with normal PT, aPTT and platelet counts was 60.0%, 7.5 and 92.5%, respectively. There was a significant shortening of aPTT in untreated diabetic as compared to both treated and non-diabetic controls (P < 0.001).
Shortening of aPTT in untreated type II diabetic patients might be useful marker in patients with diabetes. Therefore, monitoring the aPTT in newly diagnosed diabetic patients is important.
KeywordsActivated partial thromboplastin time Platelet count Prothrombin time Type II diabetes mellitus Bahir Dar Ethiopia
activated partial thromboplastin time
fasting blood sugar
international diabetic federation
random blood sugar
The authors would like to thank Bahir Dar Felege Hiwot referral hospital management and laboratory staff for kind cooperation during data collection. We also thank study participants for their willingness to participate in this study and provision of important information.
YAA participated in the design of the study, data collection, performed the statistical analysis and drafted the manuscript. MBS, MA and BE analyze and interpreted the data, and wrote the manuscript. All authors read and approved the final manuscript.
Compliance with ethical standards
This study was reviewed and approved by the School of Biomedical and Laboratory Sciences Research and Ethical Committee, College of Medicine and Health Sciences, University of Gondar. Then, after official permission was obtained from Bahir Dar Felege Hiwot referral hospital, written informed consent was obtained from every individual prior to enrolment in the study. The purpose and objectives of the study was clearly explained to the study subjects. The respondent was allowed to quit if he/she didn’t want to participate in the study. Confidentiality was maintained and withdraw at any time was allowed.
The authors declare that there is no conflict of interests regarding the publication of this manuscript.
Consent for publication
Not applicable. This manuscript does not contain any individual persons’ data.
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