Superparamagnetic CoFe2O4@Au with High Specific Absorption Rate and Intrinsic Loss Power for Magnetic Fluid Hyperthermia Applications
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CoFe2O4 nanoparticles (NPs) and surface modified with gold (Au) have been synthesized by a thermal decomposition method. The obtained NPs and formation of CoFe2O4@Au core–shell (CS) were confirmed by characterizing their structural and optical properties using X-ray powder diffraction (XRD) patterns, Fourier transform infrared spectroscopy, Raman spectroscopy, UV–Visible and photoluminescence studies. Morphological and compositional studies were carried out using high-resolution transmission electron microscopy and energy-dispersive X-ray spectroscopy, while the magnetic properties were determined using alternating gradient magnetometer and Mossbauer to define the magneto-structural effects of shell formation on the core NPs. Induction heating properties of CoFe2O4 and CoFe2O4@Au CS magnetic nanoparticles (MNPs) have been investigated and correlated with magneto-structural properties. Specific absorption rate and intrinsic loss power were calculated for these MNPs within the human tolerable range of frequency and amplitude, suggesting their potential in magnetic fluid hyperthermia therapy for possible cancer treatment.
KeywordsCoFe2O4@Au Superparamagnetic Specific absorption rate (SAR) Intrinsic loss power (ILP) Magnetic fluid hyperthermia
Author (Sandip Sabale) is thankful to University Grants Commission, New Delhi, India, for Raman Fellowship to work in USA (F. No. 5-105/2016 (IC), February 10, 2016. Authors are grateful to the Department of Science & Technology, New Delhi, for the grants under DST-FIST program (No. SR/FST/college-151/2013 (C)) to Jaysingpur College, Jaysingpur. Xiao-Ying Yu thanks the MS3 Initiative at the Pacific Northwest National Laboratory (PNNL) operated by Battelle for the Department of Energy. We thank Rachel Komorek for English editing.