Human Genomics of Mycobacterium tuberculosis Infection and Disease
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Purpose of Review
The study of the genetic basis of tuberculosis pathogenesis has benefited from powerful technological innovations, a more structured definition of latent and clinical manifestations of the disease, and the application of functional genomic approaches. This short review aims to summarize recent advances and to provide a link with results of previous human genetic studies of tuberculosis susceptibility.
Transcriptomics has been shown to be a useful tool to predict progression from latency to clinical disease while functional genomics has traced the molecular events that link pathogen-triggered gene expression and host genetics. Resistance to infection with Mycobacterium tuberculosis has been revealed to be strongly impacted by host genetics. Host genomics of clinical disease has been shown to be most powerful when focusing on carefully selected clinical entities and possibly by considering host-pathogen combinations.
Future studies need to build on the latest molecular findings to define disease subtypes to successfully elucidate the human genetic component in tuberculosis pathogenesis.
KeywordsTuberculosis Host genomics of tuberculosis Functional genomics of tuberculosis Transcript biomarkers Human genetics of infection
Research in the authors’ laboratory is supported by grants from the Canadian Institutes of Health Research (CIHR; FDN-143332) and the National Institutes of Health (NIH; R01 AI124349).
Compliance with Ethical Standards
Conflict of Interest
Both authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
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