Current Genetic Medicine Reports

, Volume 5, Issue 2, pp 100–107

Counseling At-Risk Parkinson’s Disease Cohorts: Integrating Emerging Evidence

  • Leonard L. Sokol
  • Michael J. Young
  • Joseph Jankovic
Genetic Counseling and Clinical Testing (BS LeRoy and N Callanan, Section Editors)
Part of the following topical collections:
  1. Genetic Counseling and Clinical Testing

Abstract

Purpose of Review

This article evaluates the current state of testing and counseling viewpoints for Parkinson’s disease (PD) risk gene carriers and their families.

Recent Findings

Recent discoveries of mutations in genes associated with increased risk for PD not only portend novel possibilities for targeted clinical research but also present salient challenges for genetic counseling.

Summary

A patient-centered and transparent approach to counseling that assesses preferences and communication styles is described to aid in facilitating the use of evolving evidence regarding strategies to attenuate PD phenoconversion in non-manifesting carriers.

Keywords

Parkinson’s disease LRRK2 Genetic counseling Genetic testing Genetic screening Phenoconversion Ashkenazi Jews North African Berbers 

Copyright information

© Springer Science + Business Media New York 2017

Authors and Affiliations

  • Leonard L. Sokol
    • 1
    • 2
  • Michael J. Young
    • 3
  • Joseph Jankovic
    • 4
  1. 1.University of Cincinnati College of MedicineCincinnatiUSA
  2. 2.Department of Neurology and Rehabilitation MedicineUniversity of Cincinnati Academic Health CenterCincinnatiUSA
  3. 3.Harvard Medical SchoolBostonUSA
  4. 4.Parkinson’s Disease Center and Movement Disorders Clinic, Department of NeurologyBaylor College of MedicineHoustonUSA

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