Mixed Ancestry and Disease Risk Transferability
Ancestry is the series of ancestors who form a line of descent or lineage back to an arbitrary founder or founding population. In recent years, integration of genome-wide genotype and sequence data from multiple populations worldwide has provided much insight into the identities and distributions of ancestral populations or clusters, thereby improving our understanding of historical migrations and current population structure at a sub-continental or regional level. Genetic ancestry, distinct from self-reported ancestry or ethnicity, serves both as a confounder in genetic association studies of genotypes and as a predictor in admixture mapping studies. This review focuses on the impact of genetic ancestry on transferability of genetic loci conferring disease risk.
KeywordsAncestry Admixture Disease risk Population structure
The contents of this publication are solely the responsibility of the author and do not necessarily represent the official view of the National Institutes of Health. This research was supported by the Intramural Research Program of the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (Z01HG200362).
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Conflict of interest
Dr. Daniel Shriner has no conflict of interest.
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All studies by Daniel Shriner involving animal and/or human subjects were performed after approval by the appropriate institutional review boards. When required, written informed consent was obtained from all participants.
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