The Effectiveness and Safety of Percutaneous Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate for the Treatment of Suspected Discogenic Low Back Pain: a Comprehensive Review

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Purpose of Review

Comprehensively review the effectiveness and safety of percutaneous, fluoroscopically guided, intradiscal injection of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) for the treatment of suspected discogenic low back pain.

Recent Findings

Publications in PubMed up to February 2019 were independently assessed. The literature search yielded three intradiscal PRP studies: one randomized controlled trial and two prospective cohort studies. Five intradiscal BMAC studies were identified. Four of the five prospective cohort studies were completed by the same primary author and results pertained to the same treatment group at different follow-up time points. A single case series of treatment with intradiscal BMAC was identified.


The evidence for use of percutaneous, fluoroscopy-guided, intradiscal PRP or BMAC for the treatment of suspected discogenic low back pain appears safe, potentially positive, but is limited due to low-quality studies, natural history of discogenic pain, and variable reporting characteristics. Further quality research is needed.

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Fig. 1

Change history

  • 20 December 2019

    The original version of this article unfortunately contained a mistake in the authorgroup section. Author Byron Schneider’s family name was incorrectly presented as “Schnieder”.


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Correspondence to Zachary L. McCormick.

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Zachary McCormick serves on the Board of Directors of the Spine Intervention Society. Taylor Burnham, Aaron Conger, Quinn Tate, Daniel Cushman, Richard Kendall, and Byron Schneider declare no conflicts of interest relevant to this manuscript.

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The original version of this article was revised: This article unfortunately contained a mistake in the authorgroup section. Author Byron Schneider's family name was incorrectly presented as “Schnieder”.

This article is part of the Topical Collection on Musculoskeletal Rehabilitation

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Burnham, T., Conger, A., Tate, Q. et al. The Effectiveness and Safety of Percutaneous Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate for the Treatment of Suspected Discogenic Low Back Pain: a Comprehensive Review. Curr Phys Med Rehabil Rep 7, 372–384 (2019).

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  • PRP
  • BMAC
  • Intradiscal
  • Discogenic low back pain