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Pre-operative Evaluation of Patients with Pulmonary Hypertension

  • Preoperative Evaluation (BJ Sweitzer, Section Editor)
  • Published:
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Abstract

Purpose of Review

To highlight some clinical information and recent findings about pulmonary hypertension (PH) and use them as a resource to improve perioperative care in patients affected with this disease.

Recent Findings

The last PH Consensus was held in Nice (2013) and continues to classify PH in five major groups. Although transthoracic Doppler echocardiography is often used as a first screening tool, right heart catheterization is mandatory to accurately make the diagnosis. As the natural history of PH has been changed by modern drug therapies, with current median survival rate reaching up to 9 years in low-risk patients, it is likely that anesthesiologists will need to evaluate PH patients more often. Their perioperative management remains challenging, and patients should be preferentially cared for in specialized centers.

Summary

Although the perioperative mortality of PH patients has significantly decreased over the years, morbidity remains high. Thus, a careful pre-operative evaluation and risk stratification by a multidisciplinary team is strongly encouraged as it may improve outcomes after surgery.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. McGoon MD, Benza RL, Escribano-Subias P, Jiang X, Miller DP, Peacock AJ, et al. Pulmonary arterial hypertension epidemiology and registries. J Am Coll Cardiol. 2013;62:D51–9. https://doi.org/10.1016/j.jacc.2013.10.023.

    Article  PubMed  Google Scholar 

  2. Barst RJ. Pulmonary hypertension: past, present and future. Ann Thorac Med. 2008;3:1–4. https://doi.org/10.4103/1817-1737.37832.

    Article  PubMed  PubMed Central  Google Scholar 

  3. •• Barnett CF, Alvarez P, Park MH. Pulmonary arterial hypertension diagnosis and treatment. Cardiol Clin. 2016;34:375–89. https://doi.org/10.1016/j.ccl.2016.04.006. Detailed clinical review about PAH

    Article  PubMed  Google Scholar 

  4. Rosenkranz S, Preston IR. Right heart catheterisation: best practice and pitfalls in pulmonary hypertension. Eur Respir Rev. 2015;24:642–52. https://doi.org/10.1183/16000617.0062-2015.

    Article  PubMed  Google Scholar 

  5. Bossone E, D’Andrea A, D’Alto M, Citro R, Argiento P, Ferrara F, et al. Echocardiography in pulmonary arterial hypertension: from diagnosis to prognosis. J Am Soc Echocardiogr. 2013;26:1–14. https://doi.org/10.1016/j.echo.2012.10.009.

    Article  PubMed  Google Scholar 

  6. Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2013;24:D34–41. https://doi.org/10.1016/j.jacc.2013.10.029.

    Article  Google Scholar 

  7. • Lang IM, Madani M. Update on chronic thromboembolic pulmonary hypertension. Circulation. 2014;130:50818. https://doi.org/10.1161/CIRCULATIONAHA.114.009309. Important source of information for practioners dealing with type 4 PH patients

    Article  Google Scholar 

  8. Smith ZR, Makowski CT, Awdish RL. Treatment of patients with chronic thromboembolic pulmonary hypertension: focus on riociguat. Ther Clin Risk Manag. 2016;12:957–64. https://doi.org/10.2147/TCRM.S80131.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Galiè N, Hoeper MM, Humbert M, Vachiery JL, Gibbs S, Lang I, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2009;30:2493–537. https://doi.org/10.1093/eurheartj/ehv317.

    Article  PubMed  Google Scholar 

  10. Miyamoto S, Nagaya N, Satoh T, Kyotani S, Sakamaki F, Fujita M, et al. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2000;161:487–92. https://doi.org/10.1164/ajrccm.161.2.9906015.

    Article  CAS  PubMed  Google Scholar 

  11. • Opitz CF, Hoeper MM, Gibbs JS, Kaemmerer H, Pepke-Zaba J, Coghlan JG, et al. Pre-capillary, combined, and post-capillary pulmonary hypertension: a pathophysiological continuum. J Am Coll Cardiol. 2016;68:368–78. https://doi.org/10.1016/j.jacc.2016.05.047. Detailed description about these hemodynamic types of PH

    Article  PubMed  Google Scholar 

  12. Halliday SJ, Hemnes AR, Robbins IM, Pugh ME, Zhao DX, Piana RN, et al. Prognostic value of acute vasodilator response in pulmonary arterial hypertension: beyond the ‘classic’ responders. J Heart Lung Transplant. 2015;34:312–8. https://doi.org/10.1016/j.healun.2014.10.003.

    Article  PubMed  Google Scholar 

  13. •• Farber HW, Miller DP, Poms AD, Badesch DB, Frost AE, Muros-Le Rouzic E, et al. Five-year outcomes of patients enrolled in the REVEAL Registry. Chest. 2015;148(4):1043–54. https://doi.org/10.1378/chest.15-0300. The REVEAL Registry is of outstanding importance as it updates the outcomes of patients with PAH (type 1)

    Article  PubMed  Google Scholar 

  14. Farber HW, Miller DP, McGoon MD, Frost AE, Pharm WW, Benza RL. Predicting outcomes in pulmonary arterial hypertension based on the 6-minute walk distance. J Heart Lung Transplant. 2015;34:362–8. https://doi.org/10.1016/j.healun.2014.08.020.

    Article  PubMed  Google Scholar 

  15. • Ghofrani HA, Humbert M. The role of combination therapy in managing pulmonary arterial hypertension. Eur Respir Rev. 2014;23(134):469–75. https://doi.org/10.1183/09059180.00007314. This paper calls attention to the concept of dual or triple-front therapy as an initial approach for treatment.

    Article  PubMed  Google Scholar 

  16. McLaughlin VV, Langer A, Tan M, Clements PJ, Oudiz RJ, Tapson VF, et al. Contemporary trends in the diagnosis and management of pulmonary arterial hypertension: an initiative to close the care gap. Chest. 2013;143:324–32. https://doi.org/10.1378/chest.11-3060.

    Article  CAS  PubMed  Google Scholar 

  17. Roldan T, Landzberg MJ, Deicicchi DJ, Atay JK, Waxman AB. Anticoagulation in patients with pulmonary arterial hypertension: an update on current knowledge. J Heart Lung Transplant. 2016;35:151–64. https://doi.org/10.1016/j.healun.2015.10.002.

    Article  PubMed  Google Scholar 

  18. Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, et al. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med. 1996;334(5):296–301. https://doi.org/10.1056/NEJM199602013340504.

  19. Olschewski H, Simonneau G, Galiè N, Higenbottam T, Naeije R, Rubin JL, et al. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med. 2002;347:322–9. https://doi.org/10.1056/NEJMoa020204.

    Article  CAS  PubMed  Google Scholar 

  20. Skoro-Sajer N, Lang I, Naeije R. Treprostinil for pulmonary hypertension. Vasc Health Risk Manag. 2008;4:507–13. https://doi.org/10.2169/naika.104.1652.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. •• Sitbon O, Channick R, Chin KM, Frey A, Gaine PD, Galiè N, et al. Selexipag for the treatment of pulmonary arterial hypertension. N Engl J Med. 2015;373:2522–33. https://doi.org/10.1056/NEJMoa1503184. The GRIPHON study evaluates selexipag, the most recent FDA approved drug for PH. It has a different mechanism of action, acting as a direct agonist of the prostacyclin receptor

    Article  CAS  PubMed  Google Scholar 

  22. Bonner JC, Card JW, Zeldin DC. Nanoparticle-mediated drug delivery and pulmonary hypertension. Hypertension. 2009;53:1–3. https://doi.org/10.1161/HYPERTENSIONAHA.108.122846.

    Article  CAS  Google Scholar 

  23. Sim J-Y. Nitric oxide and pulmonary hypertension. Korean J Anesthesiol. 2010;58:4–14. https://doi.org/10.4097/kjae.2010.58.14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Montani D, Chaumais MC, Savale L, Natali D, Price LC, Jaïs X, et al. Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension. Adv Ther. 2009;26:813–25. https://doi.org/10.1007/s12325-009-0064-z.

    Article  CAS  PubMed  Google Scholar 

  25. Ghofrani HA, Galiè N, Grimminger F, Grünig E, Humbert M, Jing ZC, et al. Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med. 2013;369:330–40. https://doi.org/10.1056/NEJMoa1209655.

    Article  CAS  PubMed  Google Scholar 

  26. Simonneau G, D'Armini AM, Ghofrani HA, Grimminger F, Hoeper MM, Jansa P, et al. Riociguat for the treatment of chronic thromboembolic pulmonary hypertension: a long-term extension study (CHEST-2). Eur Respir J. 2015;45:1293–302. https://doi.org/10.1183/09031936.00087114.

    Article  CAS  PubMed  Google Scholar 

  27. •• Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, VV ML, et al. Tadalafil in pulmonary arterial hypertension. N Engl J Med. 2015;373(9):834–44. https://doi.org/10.1056/NEJMoa1413687. The AMBITION trial is remarkable as it has shown significant benefits of ambrisentan and tadalafil combined, used as dual-front therapy.

    Article  PubMed  Google Scholar 

  28. • Minai OA, Yared JP, Kaw R, Subramaniam K, Hill NS. Perioperative risk and management in patients with pulmonary hypertension. Chest. 2013;144:329–40. https://doi.org/10.1378/chest.12-1752. Concise review with focus on perioperative care of PH patients

    Article  PubMed  Google Scholar 

  29. Ramakrishna G, Sprung J, Ravi BS, Chandrasekaran K, McGoon MD. Impact of pulmonary hypertension on the outcomes of noncardiac surgery: predictors of perioperative morbidity and mortality. J Am Coll Cardiol. 2005;45:1691–9. https://doi.org/10.1016/j.jacc.2005.02.055.

    Article  PubMed  Google Scholar 

  30. Kaw R, Pasupuleti V, Deshpande A, Hamieh T, Walker E, Minai OA. Pulmonary hypertension: an important predictor of outcomes in patients undergoing non-cardiac surgery. Respir Med. 2011;105:619–24. https://doi.org/10.1016/j.rmed.2010.12.006.

    Article  PubMed  Google Scholar 

  31. Memtsoudis SG, Ma Y, Chiu YL, Walz JM, Voswinckel R, Mazumdar M. Perioperative mortality in patients with pulmonary hypertension undergoing major joint replacement. Anesth Analg. 2010;111:1110–6. https://doi.org/10.1213/ANE.0b013e3181f43149.

    Article  PubMed  Google Scholar 

  32. Pritts CD, Pearl RG. Anesthesia for patients with pulmonary hypertension. Curr Opin Anaesthesiol. 2010;23:411–6. https://doi.org/10.1097/ACO.0b013e32833953fb.

    Article  PubMed  Google Scholar 

  33. Souza R, Jardim C, Fernandes CJ, Lapa MS, Rabelo R, Humbert M. NT-proBNP as a tool to stratify disease severity in pulmonary arterial hypertension. Respir Med. 2007;101:69–75. https://doi.org/10.1016/j.rmed.2006.04.014.

    Article  PubMed  Google Scholar 

  34. Malhotra AK, Ramakrishna H. N-terminal pro B type natriuretic peptide in high cardiovascular-risk patients for noncardiac surgery: what is the current prognostic evidence. Ann Card Anaesth. 2016;19:314–20. https://doi.org/10.4103/0971-9784.179636.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Yeo TC, Dujardin KS, Tei C, Mahoney DW, McGoon MD, Seward JB. Value of a doppler-derived index combining systolic and diastolic time intervals in predicting outcome in primary pulmonary hypertension. J Cardiol. 1998;81:1157–61.

    Article  CAS  Google Scholar 

  36. Forfia PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med. 2006;174:1034–41. https://doi.org/10.1164/rccm.200604-547OC.

    Article  PubMed  Google Scholar 

  37. • Pinsky MR. The right ventricle: interaction with the pulmonary circulation. Crit Care. 2016;20:266. https://doi.org/10.1186/s13054-016-1440-0. This paper reviews the pathophisyological principles of right ventricular function and their relevance on clinical practice

    Article  PubMed  PubMed Central  Google Scholar 

  38. Meyer S, McLaughlin VV, Seyfarth HJ, Bull TM, Vizza CD, Gomberg-Maitland M, et al. Outcomes of noncardiac, nonobstetric surgery in patients with PAH: an international prospective survey. Eur Respir J. 2013;41:1302–7. https://doi.org/10.1183/09031936.00089212.

    Article  PubMed  Google Scholar 

  39. Yang EI. Perioperative management of patients with pulmonary hypertension for non-cardiac surgery. Curr Rheumatol Rep. 2015;17:15. https://doi.org/10.1007/s11926-014-0490-z.

    Article  CAS  PubMed  Google Scholar 

  40. Currigan DA, Hughes RJ, Wright CE, Angus JA, Soeding PF. Vasoconstrictor responses to vasopressor agents in human pulmonary and radial arteries: an in vitro study. Anesthesiology. 2014;121:930–6. https://doi.org/10.1097/ALN.0000000000000430.

    Article  CAS  PubMed  Google Scholar 

  41. Kerbaul F, Bellezza M, Mekkaoui C, Feier H, Guidon C, Gouvernet J. Sevoflurane alters right ventricular performance but not pulmonary vascular resistance in acutely instrumented anesthetized pigs. J Cardiothorac Vasc Anesth. 2006;20:209–16. https://doi.org/10.1053/j.jvca.2005.05.017.

    Article  PubMed  Google Scholar 

  42. Kellow NH, Scott AD, White SA, Feneck RO. Comparison of the effects of propofol and isoflurane anaesthesia on right ventricular function and shunt fraction during thoracic surgery. Br J Anaesth. 1995;75(5):578–82. https://doi.org/10.1093/bja/75.5.578.

    Article  CAS  PubMed  Google Scholar 

  43. Gouvêa G, Diaz R, Auler L, Toledo R, Martinho JM. Right ventricular ejection fraction during orthotopic liver transplantation: does anesthetic technique make a difference? J Crit Care. 2010;25:657e1–6. https://doi.org/10.1016/j.jcrc.2010.02.005.

    Article  Google Scholar 

  44. Kaye AD, Baluch A, Phelps J, Baber SR, Ibrahim IN, Hoover JM, et al. An analysis of remifentanil in the pulmonary vascular bed of the cat. Anesth Analg. 2006;10:118–23. https://doi.org/10.1213/01.ane.0000184826.02943.70.

    Article  Google Scholar 

  45. Missant C, Rex S, Claus P, Derde S, Wouters PF. Thoracic epidural anaesthesia disrupts the protective mechanism of homeometric autoregulation during right ventricular pressure overload by cardiac sympathetic blockade: a randomised controlled animal study. Eur J Anaesthesiol. 2011;28:535–43. https://doi.org/10.1097/EJA.0b013e328346adf3.

    Article  PubMed  Google Scholar 

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Correspondence to Glauber Gouvêa.

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Glauber Gouvêa, Camila Santos Spiller, Rodrigo Diaz, Daniel Waetge, and Fabiano Gouvêa declare they have no conflict of interest.

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Gouvêa, G., Spiller, C.S., Diaz, R. et al. Pre-operative Evaluation of Patients with Pulmonary Hypertension. Curr Anesthesiol Rep 8, 44–51 (2018). https://doi.org/10.1007/s40140-018-0251-z

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