Current Pathobiology Reports

, Volume 6, Issue 4, pp 219–224 | Cite as

Nanoparticles Based Drug Delivery for Tissue Regeneration Using Biodegradable Scaffolds: a Review

  • Nitin Sahai
  • Nabeel Ahmad
  • Manashjit GogoiEmail author
Nanoparticle-based Drug Delivery (R Banerjee, Section Editor)
Part of the following topical collections:
  1. Nanoparticle-based Drug Delivery


Purpose of Review

Today, tissue engineering is advancing rapidly due to application of technologies like computer-aided designing; solid free-form fabrication, nanomedicine, etc. Excessive requirement of artificial organs like skin, blood vessels, cartilage, bladder, etc. is helping in its rapid development. Nanomedicines are used to bind/encapsulate in porous biodegradable scaffolds in the form of antibiotics, proteins, growth factors, specific micro- and macro-nutrients to promote the tissue regeneration.

Recent Findings

In our recent study, we reported that the chitosan-silver-based nanocomposite supports the growth of skin tissues and acts as an antibiotic agent. It was also reported that silver nanoparticles loaded with chitosan and collagen are helpful in regulating macrophage activation and migration of fibroblast.


This review highlights the application of nanomedicines in biodegradable porous tissue scaffolds applied for organ regeneration.


Scaffolds Tissue engineering Nanomedicine Antibiotic Nanocomposite 



This work was supported by North Eastern Hill University, Shillong-793022, Meghalaya, India, by providing logistic support.

Compliance with Ethical Standards

Conflict of Interest

Authors have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringNorth Eastern Hill UniversityShillongIndia
  2. 2.School of Biotechnology, IFTM UniversityMoradabadIndia

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