Cardiovascular Safety of Gabapentinoids

  • Leo F. BuckleyEmail author
  • Emad Alsarraf
Pharmacology Care (J Fanikos, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Pharmacology Care


Purpose of Review

The objective of this manuscript is to describe the cardiovascular effects of the gabapentinoids gabapentin and pregabalin.

Recent Findings

The most frequent adverse effects of gabapentin and pregabalin affect the central nervous system, such as somnolence and fatigue. Additionally, pregabalin, and a much lesser extent, gabapentin, may adversely affect the cardiovascular system. Pregabalin induces peripheral edema and may cause or exacerbate heart failure. Pregabalin use has been associated with QTc prolongation in patients taking other QTc–prolonging agents, although the relative contributions of pregabalin to QTc prolongation may be minimal. Pregabalin and gabapentin have been associated with a dose-related increased risk of atrial fibrillation. Most evidence for adverse cardiovascular effects of gabapentinoids derives from case reports and observational studies.


Clinicians should be aware of the potential for pregabalin and possibly gabapentin to contribute to cardiovascular dysfunction.


Gabapentin Pregabalin Cardiovascular Adverse drug effects 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pharmacy ServicesBrigham and Women’s HospitalBostonUSA

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