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Patient Phenotyping in OSA

  • Leon Kitipornchai
  • Andrew Jones
  • Stuart Grayson MacKayEmail author
Sleep Apnea (B Rotenberg, Section Editor)
  • 13 Downloads
Part of the following topical collections:
  1. Sleep Apnea
  2. Sleep Apnea

Abstract

Purpose of Review

OSA treatment paradigms are evolving from a “one treatment for all” philosophy to personalised therapeutic options based on anatomical and physiological phenotypes. Understanding these different phenotypes will become vital for clinicians as OSA testing and treatment become more targeted.

Recent Findings

Phenotyping of the pharynx and upper airway is vital to inform anatomical treatment options such as surgery and mandibular advancement splints. Manipulated CPAP testing allows determination of traits such as arousal threshold, muscular responsiveness and ventilatory control. Targeted therapies of each of these physiological traits have shown promise in selected patients in the research context.

Summary

Current treatment paradigms are based on anatomical therapies (CPAP, MAS, surgery); the limitations of which may be particularly evident in patients with physiological contributors to their OSA. Physiological phenotyping is an area of ongoing research into non-anatomical traits which contribute to airway obstruction.

Keywords

Obstructive sleep apnoea Phenotypes CPAP Surgery Endoscopy Upper airway Polysomnography 

Notes

Compliance with Ethical Standards

Conflict of Interest

Dr. Kitipornchai and Dr. Jones declare that they have no conflict of interest. Dr. MacKay reports non-financial support from Genio-Nyxoah Hypoglossal nerve stimulator, grants from NH&MRC, grants from Garnett Passe conjoint grant, outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Leon Kitipornchai
    • 1
    • 2
  • Andrew Jones
    • 3
    • 4
  • Stuart Grayson MacKay
    • 1
    • 3
    Email author
  1. 1.Department of Otolaryngology, Head and Neck SurgeryIllawarra Shoalhaven Local Health DistrictWollongongAustralia
  2. 2.University of QueenslandBrisbaneAustralia
  3. 3.University of WollongongWollongongAustralia
  4. 4.Department of Respiratory MedicineIllawarra Shoalhaven Local Health DistrictWollongongAustralia

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