Current Otorhinolaryngology Reports

, Volume 3, Issue 3, pp 170–179 | Cite as

Non-IgE-Mediated Rhinitis

Otolaryngic Allergy (W Mims, Section Editor)
Part of the following topical collections:
  1. Otolaryngic Allergy

Abstract

Patients with chronic rhinitis symptoms frequently present in physicians’ offices. The best-studied form of chronic rhinitis is IgE-mediated allergic rhinitis; however, the prevalence of non-allergic, non-IgE-mediated rhinitis among the chronic rhinitis population is high, and the disorder is an important cause of widespread morbidity. Despite this fact, almost no diagnostic tests or adjusted treatment schedules are established for this patient group. Chronic non-IgE-mediated rhinitis covers an extensive range of different diagnoses and comprises drug-induced, hormonal, occupational, gustatory, senile, and idiopathic rhinitis. The etiology as well as pathophysiology is only defined for some of these forms. This review summarizes the causes of non-IgE-mediated rhinitis as well as the available options for diagnostic work-up and treatment strategies. It aims at providing a tool for a more individual approach of non-allergic rhinitis patients in order to obtain an improvement of their quality of life.

Keywords

Idiopathic rhinitis Non-allergic rhinitis Capsaicin Provocation tests 

Abbreviations

ARM

Acoustic rhinometry

CDA

Cold dry air

CF

Cystic fibrosis

CGRP

Calcitonin gene-related peptide

CSS

Churg–Strauss syndrome

eNO

Exhaled nitric oxide

GPA

Granulomatosis with polyangiitis; previously Wegener’granulomatosis

HMW

High molecular weight

IB

Ipratropium bromide

IR

Idiopathic rhinitis

LAR

Local allergic rhinitis

LMW

Low molecular weight

NANC

Non-adrenergic non-cholinergic

NAR

Non-allergic rhinitis

NHR

Nasal hyperreactivity

nNO

Nasal nitric oxide

PCD

Primary ciliary dyskinesia

PNIF

Peak nasal inspiratory flow

RMM

Rhinomanometry

RUDS

Reactive upper airway dysfunction syndrome

SP

Substance P

SPT

Skin prick tests

TRPA

Transient receptor potential channel subfamily A

TRPV

Transient receptor potential channel subfamily V

Notes

References

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.European Institute for Ear, Nose and Throat DiseaseSint-Augustinus HospitalAntwerpBelgium

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