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Nanoparticles as Cell Tracking Agents in Human Ocular Cell Transplantation Therapy

  • Regenerative Medicine in Ophthalmology (D Myung, Section Editor)
  • Published:
Current Ophthalmology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Here we explore the use of nanoparticles (NPs) as cell tracking agents in ocular cell therapy.

Recent Findings

Cell transplantation is a promising strategy for treating degenerative eye disorders for which no curative therapies exist, including age-related macular degeneration (AMD), diabetic retinopathy, and glaucoma. While past and ongoing clinical trials of ocular cell transplantation have demonstrated encouraging findings, our insight into their successes and failures is limited, in large part due to the difficulty of following the fate of the transplanted cells in the human eye. In this regard, NPs warrant consideration as novel cell tracking agents in vivo, with potential advantages over other labeling methods such as fluorescent reporters and DNA barcoding. Two classes of NP—gold nanoparticles (GNPs) and superparamagnetic iron oxide nanoparticles (SPIONs)—may be particularly well-suited for longitudinal cell tracking in the eye, owing to their safety profile and compatibility with clinical imaging modalities.

Summary

GNPs and SPIONs have demonstrated potential for tracking human ocular cell therapy. Further research should be aimed at elucidating their eye-specific imaging characteristics, safety, and clearance. Our ability to accurately assess the critical processes in ocular cell transplantation—delivery, distribution, immune acceptance, retention, and integration—will help accelerate the progress of regenerative medicine in the eye.

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  1. Spencer Center for Vision Research, Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Ct, CA, 94303, Palo Alto, USA

    David C. Mundy & Jeffrey L. Goldberg

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David Mundy declares no conflict of interest. Jeffrey Goldberg reports grants from Astellas Institute for Regenerative Medicine, other from Emmecell, and personal fees from Zeiss Meditec, outside the submitted work; in addition, Dr. Goldberg has a patent use of NPs for cell delivery issued.

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Mundy, D.C., Goldberg, J.L. Nanoparticles as Cell Tracking Agents in Human Ocular Cell Transplantation Therapy. Curr Ophthalmol Rep 9, 133–145 (2021). https://doi.org/10.1007/s40135-021-00275-z

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