Glycyrrhizin Improves Fatty Liver Symptoms, Increases Adiponectin and Reduces UCP2 Expression in Wistar Rats
- 5 Downloads
Glycyrrhizin (GL) is the main bioactive component in the extract of licorice root, with beneficial effects on metabolic syndrome. This study investigates the effect of GL on biochemical and histological parameters and UCP2 gene expression in a rodent nonalcoholic steatosis model. Thirty-two male Wistar rats were classified into four groups randomly: control (normal diet with standard rat chow), high-cholesterol diet (HCD for 12 weeks) and two experimental groups (HCD for 12 weeks then shifted to normal diet plus receiving either 20 mg/kg or 100 mg/kg of glycyrrhizin for 4 weeks). At the end of experiment, in the HCD group, body weight, glucose and insulin levels were increased, lipid profile was impaired, and the markers related to liver were abnormal, while adiponectin, catalase and superoxide dismutase levels were decreased. Histological analysis of liver sections showed the appearance of hepatic fibrosis and steatosis, and UCP2 gene expression was increased significantly. GL treatment at both doses and especially at 100 mg/kg ameliorated the situation, and levels of UCP2 were decreased significantly. In conclusion, administration of glycyrrhizin can improve liver fibrosis through down-regulating the UCP2 expression.
KeywordsGlycyrrhizin UCP2 NAFLD Cholesterol
This study has been performed in the laboratory complex of Science and Research Branch of Azad University, Tehran.
Compliance with Ethical Standards
Conflict of interest
The authors declare that there is no conflict of interests to publish this manuscript.
- 5.Sacco R, Pucci L, Sivozhelezov V, Pellegrini L, Giacomelli L, Longo V (2015) Prevention of vascular damage with Lisosan G wheat extract: the in vitro basis for a clinical investigation. Eur Rev Med Pharmacol Sci 19(8):1517–1519Google Scholar
- 11.O’Connor E (2019) The role of mitochondrial uncoupling protein 3 in T cell function. Doctoral dissertation, The University of DublinGoogle Scholar
- 17.Singh S, Bigoniya P, Shrivastava B, Sharma J (2016) Hypo-glycemic profile of gymnemic acid and glycyrrhizic acid on high fructose diet related obesity induced diabetes. Int J Med Pharm Sci (IJMPS) 6(3):61–84Google Scholar
- 20.Sil R, Ray D, Chakraborti AS (2013) Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model. Indian J Exp Biol 51(2):129–138Google Scholar