Clinical Evaluation of Glycoproteins and Inflammatory Cytokines in the Serum of Dogs Affected with Canine Mammary Cancer

  • Omer Khalil BabaEmail author
  • Naresh Kumar Sood
  • Kuldip Gupta
Research Article


In canine mammary tumours, role of surface glycoproteins and cytokines is poorly understood as focus on these markers in the veterinary practice is lacking. The serum markers in 41 malignant CMT cases along with six control dogs were studied to determine their importance in the diagnosis and prognosis of CMT. The surface glycoproteins (CA 15.3 and CEA) and inflammatory cytokines (IL-8 and TNF-α) in mammary tumour cases were significantly higher than those of controls. The Kaplan–Meier survival analysis elucidated poor survival in cases with high serum marker levels. The studies implicate that serum glycoproteins and cytokines are important determinants of diagnosis and prognosis of this tumour having great relevance in veterinary oncology.


Canine CA 15.3 CEA IL8 TNFα 



The first author is highly grateful to DST INSPIRE, New Delhi, India, for fellowship during the Ph.D. programme (Fellowship No. IF 130347). The current research has been carried out at the Department of Veterinary Pathology, GADVASU, Ludhiana. The study is a part of the research project entitled “Canine Mammary Tumour as a Model for Human Breast Cancer” funded by ICAR Niche area of excellence.

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest to publish this manuscript.


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Copyright information

© The National Academy of Sciences, India 2019

Authors and Affiliations

  1. 1.Department of Veterinary Biochemistry, Shuhama, AlustengSKUAST-KashmirSrinagarIndia
  2. 2.Department of Teaching Veterinary Clinical ComplexGuru Angad Dev Veterinary and Animal Sciences UniversityLudhianaIndia
  3. 3.Department of Veterinary PathologyGuru Angad Dev Veterinary and Animal Sciences UniversityLudhianaIndia

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