A Review on Basic Biology of Bacterial Biofilm Infections and Their Treatments by Nanotechnology-Based Approaches

  • Debjani Banerjee
  • P. M. Shivapriya
  • Pavan Kumar Gautam
  • Krishna Misra
  • Amaresh Kumar Sahoo
  • Sintu Kumar SamantaEmail author


Biofilms are responsible for causing 80% of human infections including chronic infections like-cystic fibrosis, endocarditis and osteomyelitis. The growing ability of the biofilm to resist most of the available antibiotics has caused a serious threat to different life forms. Plenty of research work has already been reported, and some are ongoing to combat this serious health issue worldwide. Recent developments in nanotechnology have given a great boost in dealing biofilm infections. The unique size-dependent properties for antibacterial and antibiofilm activities provide the nanoparticles better options to eradicate biofilms. Here, the authors have discussed the basic biology of bacterial biofilm and their impact on human health. In addition, different nanotechnology-based strategies to overcome serious health issues caused by biofilm infections have been highlighted.


Bacterial biofilm infections Human health Nanotechnology Quorum sensing 



The authors Debjani Banerjee and P. M. Shivapriya are thankful to MHRD, Govt. of India and Pavan Kumar Gautam to DST for fellowship. They would like to acknowledge Indian Institute of Information Technology, Allahabad, for providing Institutional Seed Grant project for financial assistance.

Compliance with Ethical Standards

Conflict of interest

The authors have no conflict of interest to publish this manuscript.


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Copyright information

© The National Academy of Sciences, India 2019

Authors and Affiliations

  • Debjani Banerjee
    • 1
  • P. M. Shivapriya
    • 1
  • Pavan Kumar Gautam
    • 1
  • Krishna Misra
    • 1
  • Amaresh Kumar Sahoo
    • 1
  • Sintu Kumar Samanta
    • 1
    Email author
  1. 1.Department of Applied SciencesIndian Institute of Information Technology AllahabadAllahabadIndia

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