National Academy Science Letters

, Volume 35, Issue 5, pp 433–438 | Cite as

Maternal Fish Consumption and Prevention of Low Birth Weight in the Developing World

  • Bimal Prasanna Mohanty
  • Satabdi Ganguly
  • Dhanasekhar Karunakaran
  • Kajal Chakraborty
  • Anil Prakash Sharma
  • Prasanna Kumar Routray Mohapatra
  • Nihar Ranjan Nayak
Research Article


Low birth weight (LBW) is characterized by less than 2,500 g of body weight at birth. It represents about 15.5 % of total births worldwide and is a major cause of neonatal death. Most notably, 95.6 % of all LBW infants are born in the developing countries. It is primarily resulted from either preterm birth (before 37 weeks of gestation) or intrauterine growth restriction (IUGR). Infants with LBW are about 20 times at higher risk of neonatal mortality and are believed to be more susceptible to cardiovascular complications, inhibition of growth and cognitive development and chronic diseases later in life. Despite its high incidence worldwide and clinical implications, there is still no clear understanding of its causes and consequently, no specific treatments exist. Maternal nutrition before and during pregnancy plays a major role in determining the pregnancy outcome and health of the new born. Fish is a cheap source of quality animal proteins and micronutrients, and fish oil is rich in omega-3 polyunsaturated fatty acids (PUFAs), EPA and DHA. Although the beneficial effects of fish oil on human health is known since 1930s, its protective effects against various pregnancy complications, including IUGR and LBW, have been increasingly recognized during the last two decades. Despite the poor outcome of clinical trials on therapeutic use of fish oil for various pregnancy complications in Western countries, our preliminary epidemiological findings, and numerous observational and experimental studies in developing countries highlight the beneficial effects of fish consumption on pregnancy outcome, particularly in reducing the incidence of LBW. The present paper summarizes various evidences on effects of maternal fish consumption on birth weight, growth and development of infants and young children in the developing world, and emphasizes future research for better understanding of the effects of maternal fish consumption on pregnancy outcome in low socioeconomic settings.


LBW IUGR PUFAs EPA DHA FOAD Preeclampsia Micronutrient deficiency Fish consumption 



This work was supported by the Indian Council of Agricultural Research under Outreach Activity on ‘Nutrient Profiling and Evaluation of fish as a Dietary Component’. SG is thankful to ICAR for the financial support. The authors are thankful to Dr S. Ayyappan, Secretary, DARE & Director General, ICAR and Dr B. Meenakumari, DDG (Fisheries) for the encouragement and support.


  1. 1.
    United Nations Children’s Fund and World Health Organization (2004) Low birthweight: country, regional and global estimates. UNICEF, New York.
  2. 2.
    Lawn JE, Cousens S, Zupan J (2005) 4 million neonatal deaths: when? Where? Why? Lancet 365(9462):891–900CrossRefGoogle Scholar
  3. 3.
    Bamji MS (2011) Can a malnourished nation become a sporting nation? Curr Sci 101:602–604Google Scholar
  4. 4.
    Mohanty BP (2010) Fish as health food. In: Ayyappan S, Moza U, Gopalakrishnan A, Meenakumari B, Jena JK, Pandey AK (eds) Handbook of fisheries and aquaculture, 2nd edn. ICAR-DKMA. New Delhi, pp 843–861Google Scholar
  5. 5.
    Ministry of Women and Child Development. Government of India. Low Birth weight and its consequences.…/7.4%20Low%20%20birth%20weight%203.2%202008prema.pdf
  6. 6.
    Third Annual Review Report. Outreach activity 3—nutrient profiling and evaluation of fish as a dietary component. 2011. Fisheries Division, ICAR, New Delhi, p 90Google Scholar
  7. 7.
    Khanna SB, Dash K, Dwivedee SK (2007) Fetal origin of adult disease. JK Sci 9(4):206–210Google Scholar
  8. 8.
    Reddy V (1993) Child nutrition in India: priorities for the coming decade. Indian Pediatr 30:291–301Google Scholar
  9. 9.
    Baschat AA, Galan HL, Ross MG, Gabbe SG (2007) Intrauterine growth restriction. In: Gabbe SG, Niebyl JR, Simpson JL (eds) Obstetrics: normal and problem pregnancies, 5th edn. Elsevier Churchill Livingstone, Philadelphia (chap 29)Google Scholar
  10. 10.
    Pennington KA, Schlitt JM, Jackson DL, Schulz LC, Schust DJ (2012) Preeclampsia: multiple approaches for a multifactorial disease. DMM 5:9–18Google Scholar
  11. 11.
    Ekambaram P (2011) HSP70 expression and its role in preeclamptic stress. Indian J Biochem Biophys 48:243–255Google Scholar
  12. 12.
    Williams DE, Pridjian G (2007) Obstetrics. In: Rakel RE (ed) Textbook of family medicine, 7th edn. Saunders Elsevier, Philadelphia (chap 29)Google Scholar
  13. 13.
    Jensen CL (2006) Effects of n-3 fatty acids during pregnancy and lactation. Am J Clin Nutr 83(suppl):1452S–1457SGoogle Scholar
  14. 14.
    Olsen SF, Secher NJ (2002) Low consumption of seafood in early pregnancy as a risk factor for preterm delivery: prospective cohort study. BMJ 324(7335):447CrossRefGoogle Scholar
  15. 15.
    Reynolds RM, Godfrey KM, Barker M, Osmond C, Phillips DI (2007) Stress responsiveness in adult life: influence of mother’s diet in late pregnancy. J Clin Endocrinol Metabol 92(6):2208–2210CrossRefGoogle Scholar
  16. 16.
    Sandovici I, Smith NH, Nitert MD, Ackers-Johnson M, Uribe-Lewis S, Jones RH, Marquez VE, Crains W, Tadayyon M, O’Neil LP, Murrell A, Ling C, Contancia M, Ozanne SE. Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. PNAS Early Edition, pp 1–6. doi: 10.1073/pnas.1019007108
  17. 17.
    Grant WF, Gillingham MB, Batra AK, Fewkes NM, Cosmotock SM, Takahashi D, Barun TP, Grove KL, Friedman JE, Marks DL (2011) Maternal high fat diet is associated with decreased plasma n-3 fatty acids and fetal hepatic apoptosis in nonhuman primates. PLoS ONE 6(2):e17261CrossRefGoogle Scholar
  18. 18.
    Mead MN (2007) Diet and nutrition. You are what your mother ate. Environews Environ Health Prospect 115(10):492–493CrossRefGoogle Scholar
  19. 19.
    Ghosh S (1995) Preventing malnutrition: the critical period is 6 months to 2 years. Indian Pediatr 32:1057–1059Google Scholar
  20. 20.
    Deshmukh JS, Motghare DD, Zodpey SP, Wadhva SK (1998) Low birth weight and associated maternal factors in an urban area. Indian Pediatr 35:33–36Google Scholar
  21. 21.
    Hirve SS, Ganatra BR (1994) Determinants of low birth weight: a community based prospective cohort study. Indian Pediatr 31:1221–1225Google Scholar
  22. 22.
    Bamji MS (2008) Diet, nutrition and health-challenges and opportunities. Natl Acad Sci Lett 31(1&2):1–6Google Scholar
  23. 23.
    Bang HO, Dyerberg J, Hjoorne N (1976) The composition of food consumed by Greenland Eskimos. Acta Medica Scandinavica 200:69–73CrossRefGoogle Scholar
  24. 24.
    World Health Organization (2010) Joint FAO/WHO expert consultation on the risk and benefits of fish consumption. FAO Fisheries and Aquaculture Report No. 978Google Scholar
  25. 25.
    Largest ever fish health study to get under way. 2009.
  26. 26.
    Mohanty BP, Behera BK, Sharma AP (2011) Nutritional significance of small indigenous fishes in human health. Bulletin no 162. CIFRI, Barrackpore 2011.
  27. 27.
    Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR, Chance GW (1980) Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements. Early Hum Dev 4:121–129CrossRefGoogle Scholar
  28. 28.
    Martinez M (1992) Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 120:S129–S138CrossRefGoogle Scholar
  29. 29.
    Olsen SF, Grandjean P, Weihe P, Videro T (1993) Frequency of seafood intake in pregnancy as a determinant of birth weight: evidence for a dose dependent relationship. J Epidemiol Comm Health 47:436–440CrossRefGoogle Scholar
  30. 30.
    Olsen SF, Hansen HS, Sorensen TIA, Jensen B, Secher NJ, Sommer S et al (1986) Intake of marine fat, rich in n-3 poly-unsaturated fatty acids may increase birthweight by prolonging gestation. Lancet 2:367–369CrossRefGoogle Scholar
  31. 31.
    Olsen SF, Olsen J, Frische G (1990) Does fish consumption during pregnancy increase fetal growth? A study of the size of the newborn, placental weight and gestational age in relation to fish consumption during pregnancy. Int J Epidemiol 19:971–977CrossRefGoogle Scholar
  32. 32.
    Sanghvi U, Thankappan KR, Sarma PS, Sali N (2001) Assessing potential risk factors for child malnutrition in rural Kerala. J Trop Pediatr 47:50–55CrossRefGoogle Scholar
  33. 33.
    Soman CR, Damodaran M, Rajarse S, Raman KV, Vijayakumar K (1991) High morbidity and low mortility: the experience of urban preschool children in Kerala. J Trop Pediatr 37:17–24CrossRefGoogle Scholar
  34. 34.
    Kongsbak K, Thilsted SH, Wahed MA (2008) Effect of consumption of the nutrient-dense, freshwater small fish Amblypharyngodon mola on biochemical indicators of vitamin A status in Bangladeshi children: a randomized, controlled study of efficacy. Br J Nutr 99:581–597CrossRefGoogle Scholar
  35. 35.
    Mohanty BP, Das S, Bhaumik U, Sharma AP (2011) Tenualosa ilisha: a rich source of omega-3 fatty acids. Bulletin No 171. CIFRI, Barrackpore 2011.
  36. 36.
    Bloch HM, Qawasmi A (2011) Omega-3 fatty acid supplementation for the treatment of children with ADHD symptomatology: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 50:991–1000CrossRefGoogle Scholar
  37. 37.
    Hibbeln JR, Davis JM, Steer C, Emmett P, Rogers I, Williams C, Golding J (2007) Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 369:578–585CrossRefGoogle Scholar
  38. 38.
    Williams MA, Zingheim RW, King IB, Zebelman AM (1995) Omega-3 fatty acids in maternal erythrocytes and risk of preclamsia. Epidemiology 6:232–237CrossRefGoogle Scholar
  39. 39.

Copyright information

© The National Academy of Sciences, India 2012

Authors and Affiliations

  • Bimal Prasanna Mohanty
    • 1
  • Satabdi Ganguly
    • 1
  • Dhanasekhar Karunakaran
    • 1
  • Kajal Chakraborty
    • 2
  • Anil Prakash Sharma
    • 1
  • Prasanna Kumar Routray Mohapatra
    • 3
  • Nihar Ranjan Nayak
    • 4
  1. 1.ICAR-Central Inland Fisheries Research InstituteBarrackpore, KolkataIndia
  2. 2.ICAR-Central Marine Fisheries Research InstituteCochinIndia
  3. 3.Consultant GynaecologistBhubaneswarIndia
  4. 4.Department of Obstetrics and GynecologyStanford UniversityStanfordUSA

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