Journal of Pharmaceutical Investigation

, Volume 49, Issue 1, pp 149–160 | Cite as

Design, fabrication and characterization of xanthan gum/liquid-loaded porous natural rubber film

  • Thawatchai PhaechamudEmail author
  • Nutdanai Lertsuphotvanit
  • Pongsathorn Issarayungyuen
  • Takron Chantadee
Original Article


Porous natural rubber (NR) films were prepared with blocked natural rubber by solvent casting method using dichloromethane as the solvent. The various amount of xanthan gum (0–40 phr) was blended in 75 phr triethyl citrate or glycerin-loaded NR cast films. Xanthan gum markedly promoted the water sorption of these composite films. The proper compatibility of the component employed in these composite NR films was confirmed by X-ray diffractometry, thermogravimetry and differential scanning calorimetry. Although the porosity of composite NR films decreased when xanthan gum was added xanthan gum amount did not significantly affect the mechanical properties, wettability and degradability. The 20 phr xanthan gum was selected as the optimum amount to modify the liquid-loaded NR films for further as wound dressing.

Graphical abstract


Natural rubber Xanthan gum Liquid loading Physicochemical characterization 



This research work was kindly supported by the Thailand Research Fund (Grant No. RDG5650126). The authors would like to thank the Faculty of Pharmacy, Silpakorn University, Nakhon Pathom and the Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand for their facilities and support.

Compliance with ethical standards

Conflict of interest

All authors declare that there are no conflicts of interest.

Statement of human and animal rights

This article does not contain any studies with human or animal subjects performed by any of the authors.

Supplementary material

40005_2018_396_MOESM1_ESM.pdf (108 kb)
Supplementary material 1 (PDF 109 KB)


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Copyright information

© The Korean Society of Pharmaceutical Sciences and Technology 2018

Authors and Affiliations

  • Thawatchai Phaechamud
    • 1
    Email author
  • Nutdanai Lertsuphotvanit
    • 1
  • Pongsathorn Issarayungyuen
    • 1
  • Takron Chantadee
    • 1
  1. 1.Department of Pharmaceutical Technology, Faculty of PharmacySilpakorn UniversityNakhon PathomThailand

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